Nanochitosan enriched poly ε-caprolactone electrospun wound dressing membranes: A fine tuning of physicochemical properties, hemocompatibility and curcumin release profile

被引：61
作者：
Reshmi, C. R. [1 ]
Suja, P. S. [1 ]
Manaf, O. [1 ]
Sanu, P. P. [1 ]
Sujith, A. [1 ]
机构：
[1] Natl Inst Technol, Dept Chem, Mat Res Lab, Calicut 673601, Kerala, India
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 108卷
关键词：
Nanochitosan nanofibers; Antibacterial wound dressing; Hemocompatibility; Dermal tissue engineering; Sustained drug release; IN-VITRO; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; DRUG-DELIVERY; CHITOSAN; POLYCAPROLACTONE; ACID; CELL; MAT; NANOFIBERS;
D O I：
10.1016/j.ijbiomac.2017.11.035
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nanochitosan (NC) enriched Poly (epsilon-caprolactone) (PCL) nanofibrous membranes were fabricated for controlled curcumin delivery and wound dressing. A significant increase in hydrophilicity, PBS sorption, and vapour transmission were observed by incorporation of NC in PCL. Hemolysis assay, blood clot kinetics and platelet adhesion studies on PCL/NC membranes confirmed the hemocompatibility of the scaffold. NC also imparts appropriate antibacterial activity and biocompatibility promising for a wound dressing material. 15% NC (PCL/I5NC) loaded membrane exhibits excellent bioavailability and sustained release behaviour of curcumin at different pH of 7.4,5.8 and 1.2 with pH sensitive nature. Thus, it can be concluded that PCL/I5NC nanofibrous membrane is a promising material for wound dressings and transdermal patches with tunable drug releasing properties with pH stimulus. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：1261 / 1272
页数：12
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