Phenolics from Caesalpinia ferrea Mart.: antioxidant, cytotoxic and hypolipidemic activity

被引：6

作者：

Nawwar, M. A. ^{[1
]}

Hussein, S. A. ^{[1
]}

El-Mousallami, A. M. ^{[2
]}

Hashim, A. N. ^{[1
]}

Mousa, M. A. ^{[1
]}

Hetta, M. H. ^{[3
]}

Hamed, M. A. ^{[4
]}

Werner, V. ^{[5
]}

Becker, A. ^{[5
]}

Haertel, B. ^{[5
]}

Lindequist, U. ^{[5
]}

机构：

[1] Natl Res Ctr, Dept Phytochem & Plant Systemat, Div Pharmaceut Ind, Cairo, Egypt

[2] Zagazig Univ, Fac Sci, Dept Chem, Zagazig, Egypt

[3] Beni Suef Univ, Fac Pharm, Dept Pharmacognosy, Bani Suwayf, Egypt

[4] Natl Res Ctr, Div Pharmaceut Ind, Dept Therapeut Chem, Cairo, Egypt

[5] Ernst Moritz Arndt Univ Greifswald, Pharmaceut Biol, Inst Pharm, Greifswald, Germany

来源：

PHARMAZIE | 2015年 / 70卷 / 08期

关键词：

CONSTITUENTS; LEAVES; LIPIDS; SERUM; WOOD;

D O I：

10.1691/ph.2015.5526

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nine phenolics were isolated from the aqueous ethanol extract of the leaves of Caesalpinia ferrea. The isolates were characterized for the first time from that plant. The structures of all isolates (1-9) were elucidated by conventional methods, spectroscopic analysis, including 1D and 2D NMR, and by HR-ESIMS as well. The antioxidant capacities using the ORAC method and the cytotoxic activity using the neutral red assay (NRU) for that extract and three major isolates have been evaluated. In addition, the hypolipidemic activity (in vitro and in vivo) of the extract has been assessed.

引用

页码：553 / 558

页数：6

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