Paramyxoviruses: different receptors - different mechanisms of fusion

被引：46

作者：

Lorio, Ronald M. ^{[1
,2
]}

Mahon, Paul J. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Worcester, MA 01655 USA

[2] Univ Massachusetts, Sch Med, Program Immunol Virol, Worcester, MA 01655 USA

来源：

TRENDS IN MICROBIOLOGY | 2008年 / 16卷 / 04期

关键词：

D O I：

10.1016/j.tim.2008.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Para myxovirus-mediated membrane fusion usually requires an interaction between the viral-attachment and -fusion proteins. The mechanism by which this interaction regulates fusion differs between paramyxoviruses that bind to sialic acid-containing receptors and those that recognize specific proteins. The recently solved structure of the globular head of the measles virus hemagglutinin suggests that this difference might be related to the location of the receptor-binding sites on the attachment proteins of the two classes of paramyxoviruses.

引用

页码：135 / 137

页数：3

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