Inflammasomes: far beyond inflammation

被引：141
作者：
Henao-Mejia, Jorge [1 ]
Elinav, Eran [1 ]
Strowig, Till [1 ]
Flavell, Richard A. [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA
来源：
NATURE IMMUNOLOGY | 2012年 / 13卷 / 04期
关键词：
NLRP3; INFLAMMASOME; INSULIN-RESISTANCE; ACTIVATION; OBESITY; NLRC4; MICE; CASPASE-1; RECEPTORS; CRYSTALS; DEFENSE;
D O I：
10.1038/ni.2257
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Nearly a decade ago, the concept of inflammasomes was introduced. Since then, the biochemical characterization of the inflammasomes has led to a richer understanding of innate immune responses in the context of infection and sterile inflammation. This has provided the rationale for successful clinical therapies for a spectrum of hereditary periodic fever syndromes and potentially for some metabolic pathologies.
引用
收藏
页码：321 / 324
页数：4
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