Deubiquitylation and regulation of the immune response

被引：296

作者：

Sun, Shao-Cong ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 07期

关键词：

D O I：

10.1038/nri2337

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ubiquitylation is a fundamental mechanism of signal transduction that regulates immune responses and many other biological processes. Similar to phosphorylation, ubiquitylation is a reversible process that is counter-regulated by ubiquitylating enzymes and deubiquitylating enzymes (DUBs). Despite the identification of a large number of DUBs, our knowledge of the function and activities of this family of enzymes is just starting to accumulate. As described in this Review, recent studies of several DUBs, in particular CYLD and A20, show that deubiquitylation has an important role in the regulation of both innate and adaptive immune responses.

引用

页码：501 / 511

页数：11

共 114 条

[31] Ubiquitylation and cell signaling [J].

Haglund, K ;

Dikic, I .

EMBO JOURNAL, 2005, 24 (19) :3353-3359

[32] The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl [J].

Hawash, IY ;

Kesavan, KP ;

Magee, AI ;

Geahlen, RL ;

Harrison, ML .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (07) :5683-5691

[33] The ubiquitin system [J].

Hershko, A ;

Ciechanover, A .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :425-479

[34] Convergence of the NF-κB and IRF pathways in the regulation of the innate antiviral response [J].

Hiscott, John .

CYTOKINE & GROWTH FACTOR REVIEWS, 2007, 18 (5-6) :483-490

[35] Triggering the innate antiviral response through IRF-3 activation [J].

Hiscott, John .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (21) :15325-15329

[36] The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals [J].

Hitotsumatsu, Osamu ;

Ahmad, Regina-Celeste ;

Tavares, Rita ;

Wang, Min ;

Philpott, Dana ;

Turer, Emre E. ;

Lee, Bettina L. ;

Shiffin, Nataliya ;

Advincula, Rommel ;

Malynn, Barbara A. ;

Werts, Catherine ;

Ma, Averil .

IMMUNITY, 2008, 28 (03) :381-390

[37] Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD [J].

Hoevelmeyer, Nadine ;

Wunderlich, F. Thomas ;

Massoumi, Ramin ;

Jakobsen, Charlotte G. ;

Song, Jian ;

Woerns, Marcus A. ;

Merkwirth, Carsten ;

Kovalenko, Andrew ;

Aumailley, Monique ;

Strand, Dennis ;

Bruening, Jens C. ;

Galle, Peter R. ;

Wallach, David ;

Faessler, Reinhard ;

Waisman, Ari .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (11) :2615-2627

[38] Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation [J].

Iha, Hidekatsu ;

Peloponese, Jean-Marie ;

Verstrepen, Lynn ;

Zapart, Grzegorz ;

Ikeda, Fumiyo ;

Smith, C. Dahlem ;

Starost, Matthew F. ;

Yedavalli, Venkat ;

Heyninck, Karen ;

Dikic, Ivan ;

Beyaert, Rudi ;

Jeang, Kuan-Teh .

EMBO JOURNAL, 2008, 27 (04) :629-641

[39] A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha [J].

Jin, DY ;

Teramoto, H ;

Giam, CZ ;

Chun, RF ;

Gutkind, JS ;

Jeang, KT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (41) :25816-25823

[40]

JIN W, J CLIN INVE IN PRESS

← 1 2 3 4 5 6 7 8 9 10 →