Initial T cell frequency dictates memory CD8+ T cell lineage commitment

被引:370
作者
Marzo, AL
Klonowski, KD
Le Bon, A
Borrow, P
Tough, DF
Lefrançois, L
机构
[1] Univ Connecticut, Ctr Hlth, Div Immunol, Farmington, CT 06030 USA
[2] Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England
关键词
D O I
10.1038/ni1227
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Memory T cells can be divided into central memory T cell (TCM cell) and effector memory T cell (TEM cell) subsets based on homing characteristics and effector functions. Whether TEM and TCM cells represent interconnected or distinct lineages is unclear, although the present paradigm suggests that TEM and TCM cells follow a linear differentiation pathway from naive T cells to effector T cells to TEM cells to TCM cells. We show here that naive T cell precursor frequency profoundly influenced the pathway along which CD8(+) memory T cells developed. At low precursor frequency, those TEM cells generated represented a stable cell lineage that failed to further differentiate into TCM cells. These findings do not adhere to the present dogma regarding memory T cell generation and provide a means for identifying factors controlling memory T cell lineage commitment.
引用
收藏
页码:793 / 799
页数:7
相关论文
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[31]   Visualization, characterization, and turnover of CD8(+) memory T cells in virus-infected hosts [J].
Zimmermann, C ;
BrduschaRiem, K ;
Blaser, C ;
Zinkernagel, RM ;
Pircher, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1367-1375