Cancer testis antigens in sarcoma: Expression, function and immunotherapeutic application

被引：35

作者：

Wei, Ran ^{[1
,2
]}

Dean, Dylan C. ^{[1
]}

Thanindratarn, Pichaya ^{[1
]}

Hornicek, Francis J. ^{[1
]}

Guo, Wei ^{[2
]}

Duan, Zhenfeng ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Orthoped Surg, Sarcoma Biol Lab, David Geffen Sch Med, 615 Charles E Young Dr South, Los Angeles, CA 90095 USA

[2] Peking Univ Peoples Hosp, Musculoskeletal Tumor Ctr, 11 Xizhimen South St, Beijing 100044, Peoples R China

来源：

CANCER LETTERS | 2020年 / 479卷

基金：

美国国家卫生研究院;

关键词：

Cancer testis antigen; Sarcoma; Expression; Function; Immunotherapy; T-CELL RESPONSES; TUMOR-ASSOCIATED ANTIGEN; CANCER/TESTIS ANTIGENS; PROGNOSTIC RELEVANCE; NY-ESO-1; EXPRESSION; SYNOVIAL SARCOMA; GENE-EXPRESSION; NORMAL-TISSUES; MAGE-A; MELANOMA;

D O I：

10.1016/j.canlet.2019.10.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sarcomas are a group of heterogeneous malignancies of mesenchymal origin. Patient outcomes remain especially grim for those with recurrent or metastatic disease, and current therapeutic strategies have not significantly improved outcomes over the past few decades. This has led to a number of studies assessing novel therapies. Cancer testis antigens (CTAs) are tumor-associated antigens with physiologic expression in the testis and various malignancies, including sarcomas. Genes encoding CTAs include MAGE, NY-ESO-1, PRAME, TRAG-3/CSAGE, and SSX. The importance and function of CTAs in tumorigenesis have gained recognition in recent years. They are also proving as robust diagnostic and prognostic biomarkers. Therapeutically, antigens derived from CTAs are highly recognizable by T lymphocytes and therefore capable of generating a potent antitumor immune response. CTAs are, therefore, promising targets for novel immunotherapies. Here we review the emerging works on expression, function, and immunotherapeutic application of CTAs in sarcoma therapy.

引用

页码：54 / 60

页数：7

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