Transition metal homeostasis: from yeast to human disease

被引:177
作者
Bleackley, Mark R. [1 ]
MacGillivray, Ross T. A. [1 ]
机构
[1] Univ British Columbia, Dept Biochem & Mol Biol, Ctr Blood Res, Inst Life Sci, Vancouver, BC V6T 1Z3, Canada
关键词
Iron; Zinc; Copper; Manganese; Cobalt; Nickel; Transition metal homeostasis; Saccharomyces cerevisiae; Human disease; SACCHAROMYCES-CEREVISIAE ENCODES; CELLULAR PRION PROTEIN; CYTOCHROME-C-OXIDASE; MANGANESE-SUPEROXIDE-DISMUTASE; ZAP1 TRANSCRIPTIONAL ACTIVATOR; IRON-SULFUR PROTEINS; COPPER-BINDING-SITE; ZINC-DEFICIENCY; OXIDATIVE STRESS; ALZHEIMERS-DISEASE;
D O I
10.1007/s10534-011-9451-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transition metal ions are essential nutrients to all forms of life. Iron, copper, zinc, manganese, cobalt and nickel all have unique chemical and physical properties that make them attractive molecules for use in biological systems. Many of these same properties that allow these metals to provide essential biochemical activities and structural motifs to a multitude of proteins including enzymes and other cellular constituents also lead to a potential for cytotoxicity. Organisms have been required to evolve a number of systems for the efficient uptake, intracellular transport, protein loading and storage of metal ions to ensure that the needs of the cells can be met while minimizing the associated toxic effects. Disruptions in the cellular systems for handling transition metals are observed as a number of diseases ranging from hemochromatosis and anemias to neurodegenerative disorders including Alzheimer's and Parkinson's disease. The yeast Saccharomyces cerevisiae has proved useful as a model organism for the investigation of these processes and many of the genes and biological systems that function in yeast metal homeostasis are conserved throughout eukaryotes to humans. This review focuses on the biological roles of iron, copper, zinc, manganese, nickel and cobalt, the homeostatic mechanisms that function in S. cerevisiae and the human diseases in which these metals have been implicated.
引用
收藏
页码:785 / 809
页数:25
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