p-cresol sulfate and indoxyl sulfate: some clouds are gathering in the uremic toxin sky

被引：27

作者：

Evenepoel, Pieter ^{[1
]}

Glorieux, Griet ^{[2
]}

Meijers, Bjorn ^{[1
]}

机构：

[1] KUL Leuven, Dept Immunol & Microbiol, Lab Nephrol, B-3000 Leuven, Belgium

[2] Ghent Univ Hosp, Dept Internal Med, Nephrol Div, B-9000 Ghent, Belgium

来源：

KIDNEY INTERNATIONAL | 2017年 / 92卷 / 06期

关键词：

D O I：

10.1016/j.kint.2017.06.029

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

An increasing body of experimental and clinical evidence suggests that p-cresol sulfate and indoxyl sulfate contribute to the high cardiovascular burden in patients with chronic kidney disease. In a post hoc analysis on the HEMO trial, Shafi et al. failed to confirm an association between total p-cresol sulfate and indoxyl sulfate and cardiovascular outcomes in dialysis patients. Analytical issues and case-mix may explain the discrepant findings. Copyright (C) 2017, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

引用

页码：1323 / 1324

页数：2

共 7 条

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