Effects of cocaine in rats exposed to heroin

被引:60
作者
Leri, F [1 ]
Flores, J
Rajabi, H
Stewart, J
机构
[1] Univ Guelph, Dept Psychol, Guelph, ON N1G 2W1, Canada
[2] Univ British Columbia, Dept Neurosci, Vancouver, BC V5Z 1M9, Canada
[3] Concordia Univ, Ctr Studies Behav Neurobiol, Montreal, PQ H3G 1M8, Canada
基金
加拿大健康研究院;
关键词
heroin; cocaine; locomotion; self-administration; dopamine; rat;
D O I
10.1038/sj.npp.1300284
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We investigated whether chronic exposure to heroin alters responses to cocaine in ways that might explain the use of cocaine by opioid addicts. To this end, the effects of cocaine (5 and 20 mg/kg) were assessed on locomotor activity of rats chronically exposed to heroin (0.0, 3.5, 7.0, and 14.0 mg/kg/day, over 14 days, via osmotic mini- pumps), or withdrawn from heroin (1 day, acute withdrawal, and 14 days, protracted withdrawal). Chronic heroin exposure, in itself, dose dependently increased locomotion and acute cocaine administration further elevated locomotor activity in a dose-dependent and additive manner. During acute withdrawal, there was a dose-dependent decrease in locomotion that was reversed by cocaine in a dose-dependent manner. During protracted withdrawal, spontaneous locomotion normalized, but rats previously exposed to heroin displayed cross-sensitization to cocaine as indicated by small, but significant, enhanced locomotor response to 5 mg/kg of cocaine, and enhanced intravenous self-administration of low doses of cocaine (0.13 mg/kg/infusion). In a separate study, we measured extracellular dopamine (DA) in the nucleus accumbens (Acb) using in vivo microdialysis before and after acute withdrawal from heroin. During chronic exposure to heroin, basal extracellular DA was elevated dose dependently, whereas in acute withdrawal, levels were not different from those in vehicle-treated rats. In response to cocaine, however, DA activity in the Acb was significantly lower in rats withdrawn from the highest dose of heroin.
引用
收藏
页码:2102 / 2116
页数:15
相关论文
共 50 条
[41]   Effects of Levamisole on Cocaine Self-Administration by Rats [J].
Zimmermann, Zachary J. ;
Gauvin, David V. ;
Poling, Alan .
PSYCHOLOGICAL RECORD, 2017, 67 (04) :559-567
[42]   CAFFEINE EXPOSURE SENSITIZES RATS TO THE REINFORCING EFFECTS OF COCAINE [J].
HORGER, BA ;
WELLMAN, PJ ;
MORIEN, A ;
DAVIES, BT ;
SCHENK, S .
NEUROREPORT, 1991, 2 (01) :53-56
[43]   Effects of prenatal cocaine and heroin exposure on neuronal dendrite morphogenesis and spatial recognition memory in mice [J].
Lu, Ruhui ;
Liu, Xing ;
Long, Hui ;
Ma, Lan .
NEUROSCIENCE LETTERS, 2012, 522 (02) :128-133
[44]   Effects of cocaine on the discriminative stimulus and reinforcing effects of mephedrone in male rats [J].
Erwin, Laura L. ;
Nilges, Mark R. ;
Bondy, Zachary B. ;
Winsauer, Peter J. .
PSYCHOPHARMACOLOGY, 2019, 236 (03) :1043-1056
[45]   Effects of environmental enrichment on sensitivity to cocaine in female rats: importance of control rates of behavior [J].
Smith, Mark A. ;
Iordanou, Jordan C. ;
Cohen, Marika B. ;
Cole, Kathryn T. ;
Gergans, Samantha R. ;
Lyle, Megan A. ;
Schmidt, Karl T. .
BEHAVIOURAL PHARMACOLOGY, 2009, 20 (04) :312-321
[46]   Evidence for increased seizure susceptibility in rats exposed to cocaine in utero [J].
Baraban, SC ;
McCarthy, EB ;
Schwartzkroin, PA .
DEVELOPMENTAL BRAIN RESEARCH, 1997, 102 (02) :189-196
[47]   EFFECTS OF THE CALCIUM-ANTAGONIST ISRADIPINE ON COCAINE INTRAVENOUS SELF-ADMINISTRATION IN RATS [J].
MARTELLOTTA, MC ;
KUZMIN, A ;
MUGLIA, P ;
GESSA, GL ;
FRATTA, W .
PSYCHOPHARMACOLOGY, 1994, 113 (3-4) :378-380
[48]   THE VENTRAL PALLIDUM PLAYS A ROLE IN MEDIATING COCAINE AND HEROIN SELF-ADMINISTRATION IN THE RAT [J].
HUBNER, CB ;
KOOB, GF .
BRAIN RESEARCH, 1990, 508 (01) :20-29
[49]   Rats Maintained Chronically on Buprenorphine Show Reduced Heroin and Cocaine Seeking in Tests of Extinction and Drug-Induced Reinstatement [J].
Robert E Sorge ;
Heshmat Rajabi ;
Jane Stewart .
Neuropsychopharmacology, 2005, 30 :1681-1692
[50]   Effects of pregnanolone in rats discriminating cocaine [J].
Quinton, M. S. ;
Gerak, L. R. ;
Moerschbaecher, J. M. ;
Winsauer, P. J. .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2006, 85 (02) :385-392