Dysfunction of microvascular endothelial cells induced by tumor necrosis factor (TNFα):: cellular and molecular mechanism

被引：0
|
作者：
Jin, HM [1 ]
Liu, QH [1 ]
Cao, XA [1 ]
Wu, ZH [1 ]
Zhang, GP [1 ]
Zhang, M [1 ]
Sha, ZY [1 ]
机构：
[1] Shanghai Med Univ, Dept Pathophysiol, Shanghai 200032, Peoples R China
来源：
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | 2000年 / 23卷 / 2-4期
关键词：
D O I：
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中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The dysfunction of rat pulmonary microvascular endothelial cells (RPMVEC) induced by tumor necrosis factor a: (TNF alpha) was investigated in cell culture. The TNF alpha concentrations added into culture were 1000-5000 u/ml. The study was done at different steps as follows: (1) cell proliferation dynamic, (2) coagulation and anti-coagulation, (3) adhesive molecule, (4) nitric oxide (NO), (5) oncogens, and (6) apoptosis. It was concluded that attention should be paid to the metabolic disorder and dysfunction of RPMVEC induced by TNF alpha which can not be found easily according to the morphological changes. This might be the common pathway in the pathogenesis of some diseases related to TNF alpha.
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页码：109 / 112
页数：4
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