Gold-Catalyzed Direct Intermolecular Coupling of Ketones, Secondary Amines, and Alkynes: A Facile and Versatile Access to Propargylic Amines Containing a Quaternary Carbon Center

被引：69
作者：
Cheng, Ming [1 ,2 ]
Zhang, Qiang [1 ,2 ]
Hu, Xiao-Yu [1 ,2 ]
Li, Bo-Gang [1 ]
Ji, Jian-Xin [1 ]
Chan, Albert S. C. [3 ]
机构：
[1] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
[3] Hong Kong Baptist Univ, Presidents Off, Kowloon Tong, Hong Kong, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 08期
基金：
美国国家科学基金会;
关键词：
alkynes; gold salts; ketones; propargylic amines; secondary amines; C-H ACTIVATION; 3-COMPONENT MANNICH REACTION; HIGHLY EFFICIENT; DIRECT-ADDITION; TERMINAL ALKYNES; ENANTIOSELECTIVE SYNTHESIS; ALDEHYDE; IMINES; COPPER; SILVER;
D O I：
10.1002/adsc.201000914
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The first gold-catalyzed direct intermolecular coupling of ketones, secondary amines, and alkynes was achieved under mild and solvent-free conditions. The present methodology provides a promising and versatile tool for the construction of propargylic amines with a newly-formed quaternary carbon center.
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页码：1274 / 1278
页数：5
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