Genomic ancestry as a risk factor for diabetic retinopathy in patients with type 1 diabetes from an admixed population: a nested case-control study in Brazil

被引：9

作者：

Santos, Deborah Conte ^{[1
]}

de Melo, Laura Gomes Nunes ^{[2
]}

Pizarro, Marcela Haas ^{[1
]}

Barros, Bianca S. V. ^{[1
]}

Negrato, Carlos Antonio ^{[3
]}

Porto, Luis Cristovao ^{[4
]}

Silva, Dayse A. ^{[5
]}

Drummond, Karla Rezende Guerra ^{[6
]}

Muniz, Luiza Harcar ^{[1
]}

Mattos, Tessa Cerqueria Lemos ^{[7
]}

Pinheiro, Andre Araujo ^{[8
]}

Mallmann, Felipe ^{[9
]}

Leal, Franz Schubert Lopes ^{[10
]}

Malerbi, Fernando Korn ^{[11
]}

Morales, Paulo Henrique ^{[12
]}

Gomes, Marilia Brito ^{[1
]}

机构：

[1] Rio De Janeiro State Univ UERJ, Diabet Unit, Dept Internal Med, Blvd 28 Setembro,77-3 Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil

[2] Univ Estado Rio De Janeiro, Dept Ophthalmol, Rio De Janeiro, Brazil

[3] Univ Sao Paulo, Bauru, SP, Brazil

[4] Rio De Janeiro State Univ UERJ, Histocompatibil & Cryopreservat Lab HLA, Rio De Janeiro, RJ, Brazil

[5] Rio De Janeiro State Univ UERJ, DNA Diagnost Lab LDD, Rio De Janeiro, RJ, Brazil

[6] Fed Hosp Servers Rio De Janeiro, Dept Ophthalmol, Rio De Janeiro, Brazil

[7] Ctr Endocrinol & Diabet State Bahia, Dept Ophthalmol, Salvador, BA, Brazil

[8] Reg Hosp Taguatinga, Dept Ophthalmol, Brasilia, DF, Brazil

[9] Univ Fed Rio Grande do Sul, Dept Ophthalmol, Porto Alegre, RS, Brazil

[10] Univ Estadual Campinas, Dept Ophthalmol, Campinas, SP, Brazil

[11] Univ Fed Sao Paulo, Dept Endocrinol & Ophthalmol, Sao Paulo, Brazil

[12] Univ Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil

来源：

ACTA DIABETOLOGICA | 2020年 / 57卷 / 08期

关键词：

Type; 1; diabetes; Genomic ancestry; Ethnicity; Retinopathy; AFRICAN ANCESTRY; COMPLICATIONS-TRIAL/EPIDEMIOLOGY; GLYCEMIC CONTROL; PREVALENCE; HYPERTENSION; DISEASE; HEALTH; MICROALBUMINURIA; ETHNICITY; OUTCOMES;

D O I：

10.1007/s00592-020-01498-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims The influence of genetic factors on the development and progression of diabetic retinopathy is still unclear. Previous studies showed controversial results. We aimed to characterize the relationship between genomic ancestry and self-reported color/race with severe diabetic retinopathy in patients with type 1 diabetes belonging to a highly admixed population. Methods This study was a nested case-control based on data collected from a large cross-sectional, nationwide survey conducted in clinics from all five geographic regions of Brazil. For the present study, we included 414 individuals. Cases (n = 176) were considered if they had severe non-proliferative or proliferative diabetic retinopathy, and controls (n = 238) were type 1 diabetes patients without retinopathy, matched for diabetes duration by a range of 5 years. Indirect ophthalmoscopy was performed, and individual genomic ancestry was inferred using a panel of 46 ancestry informative markers. Results The backward stepwise logistic regression analysis showed that African genomic ancestry (OR 3.9, p = 0.045), HbA1c (OR 1.24, p = 0.001), glomerular filtration rate (OR 0.98, p < 0.001) and hypertension (OR 2.52, p < 0.001) were associated with severe diabetic retinopathy after adjusting for clinical and demographic data. Self-reported color/race was not statistically associated with diabetic retinopathy. Conclusions Genomic ancestry, as well as clinical variables such as hypertension, impaired glomerular filtration rate and poor diabetes control (HbA1c), was important risk factor for the development of severe diabetic retinopathy. Further studies are needed, especially in highly admixed populations, to better understand the role of genomic ancestry and possible genes that might be associated with the development and/or progression of diabetic retinopathy.

引用

页码：937 / 945

页数：9

共 40 条

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