In Vivo Mouse Models for Hepatitis B Virus Infection and Their Application

被引:34
|
作者
Du, Yanqin [1 ]
Broering, Ruth [2 ]
Li, Xiaoran [3 ]
Zhang, Xiaoyong [3 ]
Liu, Jia [4 ]
Yang, Dongliang [4 ]
Lu, Mengji [1 ]
机构
[1] Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Essen, Germany
[2] Univ Duisburg Essen, Univ Hosp Essen, Dept Gastroenterol & Hepatol, Essen, Germany
[3] Southern Med Univ, Guangdong Prov Key Lab Viral Hepatitis Res, State Key Lab Organ Failure Res, Dept Infect Dis,Nanfang Hosp, Guangzhou, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Infect Dis, Wuhan, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金
中国国家自然科学基金;
关键词
hydrodynamic injection; viral vector; transgenic mouse; liver humanized mouse; hepatitis B virus; CLOSED-CIRCULAR DNA; TRANSGENIC MICE; HEPATOCELLULAR-CARCINOMA; HYDRODYNAMIC INJECTION; HUMAN HEPATOCYTES; ADENOVIRUS VECTORS; ANTIVIRAL ACTIVITY; VIRAL PERSISTENCE; IMMUNE TOLERANCE; CHIMERIC MOUSE;
D O I
10.3389/fimmu.2021.766534
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Despite the availability of effective vaccination, hepatitis B virus (HBV) infection continues to be a major challenge worldwide. Research efforts are ongoing to find an effective cure for the estimated 250 million people chronically infected by HBV in recent years. The exceptionally limited host spectrum of HBV has limited the research progress. Thus, different HBV mouse models have been developed and used for studies on infection, immune responses, pathogenesis, and antiviral therapies. However, these mouse models have great limitations as no spread of HBV infection occurs in the mouse liver and no or only very mild hepatitis is present. Thus, the suitability of these mouse models for a given issue and the interpretation of the results need to be critically assessed. This review summarizes the currently available mouse models for HBV research, including hydrodynamic injection, viral vector-mediated transfection, recombinant covalently closed circular DNA (rc-cccDNA), transgenic, and liver humanized mouse models. We systematically discuss the characteristics of each model, with the main focus on hydrodynamic injection mouse model. The usefulness and limitations of each mouse model are discussed based on the published studies. This review summarizes the facts for considerations of the use and suitability of mouse model in future HBV studies.
引用
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页数:12
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