Safety of Recombinant VSV-Ebola Virus Vaccine Vector in Pigs

被引：27
作者：
de Wit, Emmie [1 ]
Marzi, Andrea [1 ]
Bushmaker, Trenton [1 ]
Brining, Doug [1 ]
Scott, Dana [1 ]
Richt, Juergen A. [2 ]
Geisbert, Thomas W. [3 ]
Feldmann, Heinz [1 ,4 ]
机构：
[1] NIAID, Hamilton, MT 59840 USA
[2] Kansas State Univ, Coll Vet Med, Manhattan, KS 66506 USA
[3] Univ Texas Med Branch, Galveston, TX 77555 USA
[4] Univ Manitoba, Winnipeg, MB, Canada
来源：
EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 04期
基金：
美国国家卫生研究院;
关键词：
VESICULAR STOMATITIS-VIRUS; NONHUMAN-PRIMATES; GLYCOPROTEINS;
D O I：
10.3201/eid2104.142012
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.
引用
收藏
页码：702 / 704
页数：3
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