A new Antennapedia-derived vector for intracellular delivery of exogenous compounds

被引：13

作者：

García-Echeverría, C

Jiang, L

Ramsey, TM

Sharma, SK

Chen, YNP ^{[1
]}

机构：

[1] Novartis Pharma Inc, Oncol Res, CH-4002 Basel, Switzerland

[2] Novartis Pharmaceut Corp, Oncol Res, Summit, NJ 07901 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)00208-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe the design, synthesis and cell translocation capacity of a peptide derived from the third alpha -helix of the homeodomain of Antennapedia. The new sequence appears to be an efficient and nontoxic means to deliver a covalently linked peptide cargo into cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1363 / 1366

页数：4

共 20 条

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[2] PREPARATION AND APPLICATION OF THE 5-(4-(9-FLUORENYLMETHYLOXYCARBONYL)AMINOMETHYL-3,5-DIMETHOXYPHENOXY)VALERIC ACID (PAL) HANDLE FOR THE SOLID-PHASE SYNTHESIS OF C-TERMINAL PEPTIDE AMIDES UNDER MILD CONDITIONS [J].