The Role of Lymphatic Niches in T Cell Differentiation

被引：14

作者：

Capece, Tara ^{[1
]}

Kim, Minsoo ^{[1
]}

机构：

[1] Univ Rochester, Dept Microbiol & Immunol, David H Smith Ctr Vaccine Biol & Immunol, 601 Elmwood Ave, Rochester, NY 14642 USA

来源：

MOLECULES AND CELLS | 2016年 / 39卷 / 07期

关键词：

CD8 T cell; chemokine; immune memory; lymph node; T cell; SECONDARY LYMPHOID ORGANS; HIGH ENDOTHELIAL VENULES; SUBCAPSULAR SINUS MACROPHAGES; FIBROBLASTIC RETICULAR CELLS; CXC CHEMOKINE RECEPTOR-5; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; B-CELLS; STEM-CELLS; SYNAPSE FORMATION;

D O I：

10.14348/molcells.2016.0089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long-term immunity to many viral and bacterial pathogens requires CD8(+) memory T cell development, and the induction of long-lasting CD8(+) memory T cells from a naive, undifferentiated state is a major goal of vaccine design. Formation of the memory CD8(+) T cell compartment is highly dependent on the early activation cues received by naive CD8(+) T cells during primary infection. This review aims to highlight the cellularity of various niches within the lymph node and emphasize recent evidence suggesting that distinct types of T cell activation and differentiation occur within different immune contexts in lymphoid organs.

引用

页码：515 / 523

页数：9

共 155 条

[1] Signals delivered through TCR instruct IL-12 receptor (IL-12R) expression:: IL-12 and tumor necrosis factor-α synergize for IL-12R expression at low antigen dose [J].

Ahlers, JD ;

Belyakov, IM ;

Matsui, S ;

Berzofsky, JA .

INTERNATIONAL IMMUNOLOGY, 2001, 13 (11) :1433-1442

[2] The CD8+ memory T-cell state of readiness is actively maintained and reversible [J].

Allam, Atef ;

Conze, Dietrich B. ;

Torchia, Maria Letizia Giardino ;

Munitic, Ivana ;

Yagita, Hideo ;

Sowell, Ryan T. ;

Marzo, Amanda L. ;

Ashwell, Jonathan D. .

BLOOD, 2009, 114 (10) :2121-2130

[3]

ALZONA M, 1994, J IMMUNOL, V153, P2861

[4] β1 integrin deficiency impairs migration and differentiation of mouse embryonic stem cell derived neurons [J].

Andressen, C ;

Arnhold, S ;

Puschmann, M ;

Bloch, W ;

Hescheler, J ;

Fässler, R ;

Addicks, K .

NEUROSCIENCE LETTERS, 1998, 251 (03) :165-168

[5] A chemokine-driven positive feedback loop organizes lymphoid follicles [J].

Ansel, KM ;

Ngo, VN ;

Hyman, PL ;

Luther, SA ;

Förster, R ;

Sedgwick, JD ;

Browning, JL ;

Lipp, M ;

Cyster, JG .

NATURE, 2000, 406 (6793) :309-314

[6] Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes [J].

Azar, Georges A. ;

Lemaitre, Fabrice ;

Robey, Ellen A. ;

Bousso, Philippe .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (08) :3675-3680

[7] Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes [J].

Bajenoff, Marc ;

Egen, Jackson G. ;

Koo, Lily Y. ;

Laugier, Jean Pierre ;

Brau, Frederic ;

Glaichenhaus, Nicolas ;

Germain, Ronald N. .

IMMUNITY, 2006, 25 (06) :989-1001

[8] Secondary Replicative Function of CD8+ T Cells That Had Developed an Effector Phenotype [J].

Bannard, Oliver ;

Kraman, Matthew ;

Fearon, Douglas T. .

SCIENCE, 2009, 323 (5913) :505-509

[9] IFN-γ and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4+ but not CD8+ T cells [J].

Barbi, Joseph ;

Oghumu, Steve ;

Lezama-Davila, Claudio M. ;

Satoskar, Abhay R. .

BLOOD, 2007, 110 (06) :2215-2216

[10] A TCR Affinity Threshold Regulates Memory CD4 T Cell Differentiation following Vaccination [J].

Baumgartner, Christina K. ;

Yagita, Hideo ;

Malherbe, Laurent P. .

JOURNAL OF IMMUNOLOGY, 2012, 189 (05) :2309-2317

← 1 2 3 4 5 6 7 8 9 10 →