SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL 2-SUBSTITUTED MERCAPTOBENZIMIDAZOLE DERIVATIVES.

被引：0

作者：

Reddy, Malladi Srinivas ^{[1
]}

Anisetti, Ravinder Nath ^{[1
]}

Prasad, K. Durga ^{[2
]}

Sannigrahi, Santanu ^{[3
]}

Reddy, P. Arvinda ^{[4
]}

机构：

[1] Osmania Univ, Univ Coll Technol, Hyderabad 500007, Andhra Pradesh, India

[2] Natco Res Ctr, Lab 4, Hyderabad, Andhra Pradesh, India

[3] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata 700032, W Bengal, India

[4] CL Baid Metha Coll Pharm, Dept Pharmaceut Chem, Madras 600096, Tamil Nadu, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2011年 / 44卷 / 11期

关键词：

2-mercapto benzimidazole; acid chlorides; anti-ulcer; anti-microbial; HELICOBACTER-PYLORI AGENTS; BENZIMIDAZOLE DERIVATIVES;

D O I：

10.1007/s11094-011-0537-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and biological assessment of six novel 2-substituted mercaptobenzimidazole derivatives is performed. The title compounds are characterized by their analytical and spectral data. All the synthesized compounds are screened for their anti-ulcer and anti-microbial activity. 2-(1H-benzimidazole-2-sulfinyl) -N-(4-benzyloxy-phenyl)-acetamide, N-(4-benzyloxy-phenyl)-4-(1H-benzimidazole-2-sulfinyl)-butyramide, N-(4-benzyloxy phenyl)-4-(5-methoxy 1H-benzimidazole-2-sulfinyl)-butyramide showed significant antiulcer activity. All the compounds moderate antibacterial and antifungal activity.

引用

页码：642 / 645

页数：4

共 19 条

[1] Synthesis, and antiprotozoal and antibacterial activities of S-substituted 4,6-dibromo- and 4,6-dichloro-2-mercaptobenzimidazoles [J].

Andrzejewska, M ;

Yepez-Mulia, L ;

Tapia, A ;

Cedillo-Rivera, R ;

Laudy, AE ;

Starosciak, BJ ;

Kazimierczuk, Z .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, 21 (2-3) :323-329

[2]

[Anonymous], [No title captured]

[3]

[Anonymous], [No title captured]

[4] Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives [J].

Ansari, K. F. ;

Lal, C. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (10) :4028-4033

[5]

FATMA N, 1988, Indian Journal of Pharmaceutical Sciences, V50, P265

[6] Benzimidazole 2′-isonucleosides:: Design, synthesis, and antiviral activity of 2-substituted-5,6-dichlorobenzimidazole 2′-isonucleosides [J].

Freeman, GA ;

Selleseth, DW ;

Rideout, JL ;

Harvey, RJ .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2000, 19 (1-2) :155-174

[7]

Gillespie S., 1994, MED MICROBIOLOGY ILL

[8] NOVEL POTENTIAL ANTI-CANCER AGENTS DERIVED FROM BENZIMIDAZOLE [J].

IBRAHIM, ESA ;

OMAR, AMME ;

KHALIL, MA .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1980, 69 (11) :1348-1350

[9] Antileishmanial activity of the antiulcer agent omeprazole [J].

Jiang, SP ;

Meadows, J ;

Anderson, SA ;

Mukkada, AJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (08) :2569-2574

[10] Novel structures derived from 2-[[(2-Pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, part 1 [J].

Kühler, TC ;

Swanson, M ;

Christenson, B ;

Klintenberg, AC ;

Lamm, B ;

Fägerhag, J ;

Gatti, R ;

Ölwegård-Halvarsson, M ;

Shcherbuchin, V ;

Elebring, T ;

Sjöström, JE .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (19) :4282-4299

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