Umbilical Cord Mesenchymal Stem/Stromal Cells Potential to Treat Or-gan Disorders; An Emerging Strategy

被引:24
作者
Ahani-Nahayati, Milad [1 ]
Niazi, Vahid [1 ]
Moradi, Alireza [2 ]
Pourjabbar, Bahareh [1 ]
Roozafzoon, Reza [1 ,3 ]
Baradaran-Rafii, Alireza [1 ,3 ]
Keshel, Saeed Heidari [4 ,5 ]
机构
[1] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Tehran, Iran
[2] Iran Univ Med Sci, Sch Med, Dept Physiol, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Med Nanotechnol Res Ctr, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Ophthalm Res Ctr, Tehran, Iran
[5] Univ S Florida, Dept Ophthalmol, Tampa, FL 33620 USA
关键词
Umbilical cord mesenchymal stem; stromal cells (UC-MSCs); isolation; immunomodulation; cell-based therapy; re-generative medicine; bone marrow; SOMATIC STEM-CELLS; HYALURONIC-ACID HYDROGEL; STROMAL CELLS; RABBIT MODEL; MYOCARDIAL REGENERATION; CARTILAGE REPAIR; LIVER-DISEASE; LUNG INJURY; UC-MSC; BLOOD;
D O I
10.2174/1574888X16666210907164046
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Currently, Mesenchymal Stem/Stromal Cells (MSCs) have attracted growing attention in the context of cell-based therapy in regenerative medicine. Following the first successful procurement of human MSCs from Bone Marrow (BM), these cells isolation has been conducted from variStem/Stromal Cells (UC-MSCs) can be acquired by a non-invasive plan and simply cultured, and thereby signifies their superiority over MSCs derived from other sources for medical purposes. Due to their unique attributes, including self-renewal, multipotency, and accessibility concomitant with their immunosuppressive competence and lower ethical concerns, UC-MSCs therapy is described as encouraging therapeutic options in cell-based therapies. Regardless of their unique aptitude to adjust inflammatory response during tissue recovery and delivering solid milieu for tissue restoration, UC-MSCs can be differentiated into a diverse spectrum of adult cells (e.g., osteoblast, chondrocyte, type II alveolar, hepatocyte, and cardiomyocyte). Interestingly, they demonstrate a prolonged survival and longer telomeres compared with MSCs derived from other sources, suggesting that UC-MSCs are desired source to use in regenerative medicine. In the present review, we deliver a brief review of UC-MSCs isolation, expansion concomitantly with immunosuppressive activities, and try to collect and discuss recent pre-clinical and clinical researches based on the use of UC-MSCs in regenerative medicine, focusing on with special focus on in vivo researches.
引用
收藏
页码:126 / 146
页数:21
相关论文
共 149 条
[1]  
Abo-Elkheir W, 2017, AM J STEM CELLS, V6, P23
[2]   Stem cell in neurodegenerative disorders; an emerging strategy [J].
Ahani-Nahayati, Milad ;
Shariati, Ali ;
Mahmoodi, Mahnaz ;
Zekiy, Angelina Olegovna ;
Javidi, Kamran ;
Shamlou, Somayeh ;
Mousakhani, Akbar ;
Zamani, Majid ;
Hassanzadeh, Ali .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2021, 81 (04) :291-311
[3]   Role of VEGF-A in angiogenesis promoted by umbilical cord-derived mesenchymal stromal/stem cells: in vitro study [J].
Arutyunyan, Irina ;
Fatkhudinov, Timur ;
Kananykhina, Evgeniya ;
Usman, Natalia ;
Elchaninov, Andrey ;
Makarov, Andrey ;
Bolshakova, Galina ;
Goldshtein, Dmitry ;
Sukhikh, Gennady .
STEM CELL RESEARCH & THERAPY, 2016, 7
[4]   Platelet lysate as a substitute for animal serum for the ex-vivo expansion of mesenchymal stem/stromal cells: present and future [J].
Astori, Giuseppe ;
Amati, Eliana ;
Bambi, Franco ;
Bernardi, Martina ;
Chieregato, Katia ;
Schaefer, Richard ;
Sella, Sabrina ;
Rodeghiero, Francesco .
STEM CELL RESEARCH & THERAPY, 2016, 7
[5]   Human unrestricted somatic stem cells loaded in nanofibrous PCL scaffold and their healing effect on skin defects [J].
Bahrami, Hoda ;
Keshel, Saeed Heidari ;
Chari, Aliakbar Jafari ;
Biazar, Esmaeil .
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2016, 44 (06) :1556-1560
[6]   Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy]) [J].
Bartolucci, Jorge ;
Verdugo, Fernando J. ;
Gonzalez, Paz L. ;
Larrea, Ricardo E. ;
Abarzua, Ema ;
Goset, Carlos ;
Rojo, Pamela ;
Palma, Ivan ;
Lamich, Ruben ;
Pedreros, Pablo A. ;
Valdivia, Gloria ;
Lopez, Valentina M. ;
Nazzal, Carolina ;
Alcayaga-Miranda, Francisca ;
Cuenca, Jimena ;
Brobeck, Matthew J. ;
Patel, Amit N. ;
Figueroa, Fernando E. ;
Khoury, Maroun .
CIRCULATION RESEARCH, 2017, 121 (10) :1192-+
[7]   Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site [J].
Ben Nasr, Moufida ;
Vergani, Andrea ;
Avruch, James ;
Liu, Liye ;
Kefaloyianni, Eirini ;
D'Addio, Francesca ;
Tezza, Sara ;
Corradi, Domenico ;
Bassi, Roberto ;
Valderrama-Vasquez, Alessandro ;
Usuelli, Vera ;
Kim, James ;
Azzi, Jamil ;
El Essawy, Basset ;
Markmann, James ;
Abdi, Reza ;
Fiorina, Paolo .
ACTA DIABETOLOGICA, 2015, 52 (05) :917-927
[8]  
Berebichez-Fridman Roberto, 2018, Sultan Qaboos Univ Med J, V18, pe264, DOI 10.18295/squmj.2018.18.03.002
[9]   Comparative analysis of human Wharton's jelly mesenchymal stem cells derived from different parts of the same umbilical cord [J].
Bharti, Dinesh ;
Shivakumar, Sharath Belame ;
Park, Ji-Kwon ;
Ullah, Imran ;
Subbarao, Raghavendra Baregundi ;
Park, Ji-Sung ;
Lee, Sung-Lim ;
Park, Bong-Wook ;
Rho, Gyu-Jin .
CELL AND TISSUE RESEARCH, 2018, 372 (01) :51-65
[10]   Unrestricted Somatic Stem Cells Loaded in Nanofibrous Scaffolds as Potential Candidate for Skin Regeneration [J].
Biazar, E. ;
Keshel, S. Heidari .
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2014, 63 (14) :741-752