Long-term update of the 24954 EORTC phase III trial on larynx preservation

被引：26

作者：

De Figueiredo, B. Henriques ^{[1
]}

Fortpied, C. ^{[2
]}

Menis, J. ^{[2
]}

Lefebvre, J. L. ^{[3
]}

Barzan, L. ^{[4
]}

de Raucourt, D. ^{[5
]}

Geoffrois, L. ^{[6
]}

Giurgea, L. ^{[2
]}

Hupperets, P. ^{[7
]}

Leemans, C. R. ^{[8
]}

Licitra, L. ^{[9
]}

Rolland, F. ^{[10
]}

Tesselaar, M. ^{[11
]}

Vermorken, J. B. ^{[12
]}

Gregoire, V. ^{[1
]}

机构：

[1] Catholic Univ Louvain, St Luc Univ Hosp, Dept Radiat Oncol, Inst Rech Expt & Clin, Brussels, Belgium

[2] EORTC Headquarters, Brussels, Belgium

[3] Ctr Oscar Lambret, Dept Head & Neck Canc, Lille, France

[4] Ctr Riferimento Oncol, Dept Surg, Aviano, Italy

[5] Ctr Francois Baclesse, Dept Head & Neck Surg, Caen, France

[6] Ctr Alexis Vautrin, Dept Med Oncol, Nancy, France

[7] Univ Hosp, Dept Internal Med, Maastricht, Netherlands

[8] Vrije Univ Amsterdam, Ctr Canc, Med Ctr, Dept Otolaryngol Head & Neck Surg, Amsterdam, Netherlands

[9] Fdn IRCCS Ist Tumori, Dept Head & Neck Med Oncol, Milan, Italy

[10] Inst Cancerol Ouest, Dept Oncol, Nantes, France

[11] Univ Hosp, Dept Radiotherapy, Leiden, Netherlands

[12] Univ Antwerp Hosp, Dept Med Oncol, Edegem, Belgium

来源：

EUROPEAN JOURNAL OF CANCER | 2016年 / 65卷

关键词：

Larynx preservation; Radiochemotherapy; Late toxicity; CHEMOTHERAPY; CANCER; HEAD;

D O I：

10.1016/j.ejca.2016.06.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The long-term results of the EORTC 24954 trial comparing sequential versus alternating chemotherapy and radiotherapy (RT) for patients with locally advanced laryngeal and hypopharyngeal cancer are reported. From 1996 to 2004, 450 patients were randomly assigned (1-1) to a sequential arm (SA = induction cisplatin-5fluorouracil followed by a 70Gy-RT for the responders or a total laryngectomy and post-operative RT for the non-responders) and an alternating arm (AA = cisplatin-5fluorouracil alternated with three 2-week courses of 20 Gy-RT for a total dose of 60 Gy). Median follow-up was 10.2 years. Ten-year survival with functional larynx (primary end-point) and overall survival were similar in both arms (18.7% and 33.6% in SA versus 18.3% and 31.6% in AA). Late toxicity was also similar; however, a trend for higher larynx preservation and better laryngeal function was observed in AA. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：109 / 112

页数：4

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