Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies

被引:314
作者
Soedamah-Muthu, Sabita S. [1 ]
Ding, Eric L. [2 ,3 ,4 ]
Al-Delaimy, Wael K. [5 ]
Hu, Frank B. [2 ,3 ,4 ]
Engberink, Marielle F. [1 ]
Willett, Walter C. [2 ,3 ,4 ]
Geleijnse, Johanna M. [1 ]
机构
[1] Wageningen Univ, Div Human Nutr, NL-6700 EV Wageningen, Netherlands
[2] Harvard Univ, Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA 02115 USA
[3] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA
[4] Harvard Univ, Sch Med, Boston, MA USA
[5] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA
关键词
CORONARY-HEART-DISEASE; BLOOD-PRESSURE; RISK-FACTORS; DIETARY PATTERNS; FOLLOW-UP; VITAMIN-D; POOLED ANALYSIS; CALCIUM INTAKE; LOW-FAT; STROKE;
D O I
10.3945/ajcn.2010.29866
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: The consumption of dairy products may influence the risk of cardiovascular disease (CVD) and total mortality, but conflicting findings have been reported. Objective: The objective was to examine the associations of milk, total dairy products, and high- and low-fat dairy intakes with the risk of CVD [including coronary heart disease (CHD) and stroke] and total mortality. Design: PubMed, EMBASE, and SCOPUS were searched for articles published up to February 2010. Of >5000 titles evaluated, 17 met the inclusion criteria, all of which were original prospective cohort studies. Random-effects meta-analyses were performed with summarized dose-response data. Milk as the main dairy product was pooled in these analyses. Results: In 17 prospective studies, there were 2283 CVD, 4391 CHD, 15,554 stroke, and 23,949 mortality cases. A modest inverse association was found between milk intake and risk of overall CVD [4 studies; relative risk (RR): 0.94 per 200 mL/d; 95% CI: 0.89, 0.99]. Milk intake was not associated with risk of CHD (6 studies; RR: 1.00; 95% CI: 0.96, 1.04), stroke (6 studies; RR: 0.87; 95% CI: 0.72, 1.05), or total mortality (8 studies; RR per 200 mL/d: 0.99; 95% CI: 0.95, 1.03). Limited studies of the association of total dairy products and of total high-fat and total low-fat dairy products (per 200 g/d) with CHD showed no significant associations. Conclusion: This dose-response meta-analysis of prospective studies indicates that milk intake is not associated with total mortality but may be inversely associated with overall CVD risk; however, these findings are based on limited numbers. Am J Clin Nutr 2011;93:158-71.
引用
收藏
页码:158 / 171
页数:14
相关论文
共 59 条
[1]  
*2 WORLD CANC RES, 2008, P NUTR SOC, V67, P253
[2]   Effect of dietary calcium and milk consumption on risk of thromboembolic stroke in older middle-aged men - The Honolulu Heart Program [J].
Abbott, RD ;
Curb, JD ;
Rodriguez, BL ;
Sharp, DS ;
Burchfiel, CM ;
Yano, K .
STROKE, 1996, 27 (05) :813-818
[3]   A prospective study of calcium intake from diet and supplements and risk of ischemic heart disease among men [J].
Al-Delaimy, WK ;
Rimm, E ;
Willett, WC ;
Stampfer, MJ ;
Hu, FB .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2003, 77 (04) :814-818
[4]   The effect of low-fat versus whole-fat dairy product intake on blood pressure and weight in young normotensive adults [J].
Alonso, A. ;
Zozaya, C. ;
Vazquez, Z. ;
Alfredo Martinez, J. ;
Martinez-Gonzalez, M. A. .
JOURNAL OF HUMAN NUTRITION AND DIETETICS, 2009, 22 (04) :336-342
[5]   Dietary Phosphorus, Blood Pressure, and Incidence of Hypertension in the Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis [J].
Alonso, Alvaro ;
Nettleton, Jennifer A. ;
Ix, Joachim H. ;
de Boer, Ian H. ;
Folsom, Aaron R. ;
Bidulescu, Aurelian ;
Kestenbaum, Bryan R. ;
Chambless, Lloyd E. ;
Jacobs, David R., Jr. .
HYPERTENSION, 2010, 55 (03) :776-U109
[6]  
[Anonymous], FOOD PORT SIZ
[7]   A clinical trial of the effects of dietary patterns on blood pressure [J].
Appel, LJ ;
Moore, TJ ;
Obarzanek, E ;
Vollmer, WM ;
Svetkey, LP ;
Sacks, FM ;
Bray, GA ;
Vogt, TM ;
Cutler, JA ;
Windhauser, MM ;
Lin, PH ;
Karanja, N .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (16) :1117-1124
[8]  
Appleby PN, 1999, AM J CLIN NUTR, V70, p525S, DOI 10.1093/ajcn/70.3.525s
[9]   Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk factors in healthy older adults [J].
Barr, SI ;
McCarron, DA ;
Heaney, RP ;
Dawson-Hughes, B ;
Berga, SL ;
Stern, JS ;
Oparil, S .
JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION, 2000, 100 (07) :810-817
[10]  
BEGG CB, 1985, STAT MED, V4, P1, DOI 10.1002/sim.4780040103