Influence of Glycemic Control on Tympanic Membrane Healing in Diabetic Rats

被引：4
作者：
Kaftan, Holger [1 ]
Reuther, Lars [1 ]
Miehe, Baerbel [2 ]
Hosemann, Werner [1 ]
Kloeting, Ingrid [3 ]
机构：
[1] Ernst Moritz Arndt Univ Greifswald, Dept Otorhinolaryngol & Head & Neck Surg, D-17475 Greifswald, Germany
[2] Ernst Moritz Arndt Univ Greifswald, Inst Anat & Cell Biol, D-17475 Greifswald, Germany
[3] Ernst Moritz Arndt Univ Greifswald, Div Lab Anim Sci, Inst Pathophysiol, D-17475 Greifswald, Germany
来源：
LARYNGOSCOPE | 2011年 / 121卷 / 04期
关键词：
Tympanic membrane; wound healing; diabetes; glycemic control; rat;
D O I：
10.1002/lary.21426
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objectives/Hypothesis: It is generally assumed that glycemic control in diabetic patients is important in optimizing wound healing. The goal of this study was to examine tympanic membrane (TM) wound healing in spontaneously diabetic rats depending on the diabetic metabolic state compared to nondiabetic control animals. Study Design: Prospective controlled study in experimental animals. Methods: Right-sided myringotomy was performed in 20 normoglycemic rats, 17 well-compensated, and 23 poorly compensated diabetic rats. TMs were observed for a total of 3 weeks. Effect of diabetic metabolic state on the healing of the TMs was evaluated by closure rates and histology. Results: Diabetic rats showed a significant delay in TM wound healing compared to the control group, but there were no significant differences between both diabetes groups. Conclusions: Glycemic control does not influence TM wound repair in an animal model of type 1 diabetes.
引用
收藏
页码：823 / 827
页数：5
相关论文
共 17 条
  • [1] [Anonymous], 1984, Analysis of survival data
  • [2] Bitar MS, 1998, AM J PATHOL, V152, P547
  • [3] Decrease of collagen deposition in wound repair in type I diabetes independent of glycemic control
    Black, E
    Vibe-Petersen, J
    Jorgensen, LN
    Madsen, SM
    Ågren, MS
    Holstein, PE
    Perrild, H
    Gottrup, F
    [J]. ARCHIVES OF SURGERY, 2003, 138 (01) : 34 - 40
  • [4] The molecular biology of chronic wounds and delayed healing in diabetes
    Blakytny, R.
    Jude, E.
    [J]. DIABETIC MEDICINE, 2006, 23 (06) : 594 - 608
  • [5] Follak N, 2004, HISTOL HISTOPATHOL, V19, P473, DOI 10.14670/HH-19.473
  • [6] Gavin JR, 1999, DIABETES CARE, V22, pS5
  • [7] STUDIES OF WOUND-HEALING IN EXPERIMENTAL DIABETES-MELLITUS
    GOODSON, WH
    HUNT, TK
    [J]. JOURNAL OF SURGICAL RESEARCH, 1977, 22 (03) : 221 - 227
  • [8] ENDOGENOUS VERSUS TOXIN-INDUCED DIABETES IN RATS - A MECHANICAL COMPARISON OF 2 SKIN WOUND-HEALING MODELS
    GREENWALD, DP
    SHUMWAY, S
    ZACHARY, LS
    LABARBERA, M
    ALBEAR, P
    TEMANER, M
    GOTTLIEB, LJ
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 1993, 91 (06) : 1087 - 1093
  • [9] Kaftan H, 2008, HNO, V56, P145, DOI 10.1007/s00106-007-1574-0
  • [10] Diabetes and hypertension in rodent models
    Kloting, I
    Berg, S
    Kovacs, P
    Voigt, B
    Vogt, L
    Schmidt, S
    [J]. LIPIDS AND SYNDROMES OF INSULIN RESISTANCE: FROM MOLECULAR BIOLOGY TO CLINICAL MEDICINE, 1997, 827 : 64 - 84
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