The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients

被引：140

作者：

Yuan, Jing ^{[1
]}

Zou, Rougrong ^{[1
]}

Zeng, Lijiao ^{[1
]}

Kou, Shanglong ^{[1
]}

Lan, Jianfeng ^{[1
]}

Li, Xiaohe ^{[1
]}

Liang, Yanhua ^{[1
]}

Ding, Xiaoyan ^{[1
]}

Tan, Guoyu ^{[1
]}

Tang, Shenghong ^{[1
]}

Liu, Lei ^{[1
]}

Liu, Yingxia ^{[1
]}

Pan, Yanchao ^{[1
]}

Wang, Zhaoqin ^{[1
]}

机构：

[1] Shenzhen Third Peoples Hosp, Diag & Treatment Infect Dis Res Lab, Shenzhen 518112, Peoples R China

来源：

INFLAMMATION RESEARCH | 2020年 / 69卷 / 06期

关键词：

COVID-19; Clearance ratio; LDH; CK; RESPIRATORY SYNDROME CORONAVIRUS; SARS; RIBAVIRIN;

D O I：

10.1007/s00011-020-01342-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Objective This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People's Hospital, enrolled from Jan 5 to Feb 13, 2020. Methods The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. Results COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-alpha + lopinavir/ritonavir or IFN-alpha + lopinavir/ritonavir + ribavirin. Conclusions Therapeutic regimens of IFN-alpha + lopinavir/ritonavir and IFN-alpha + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection.

引用

页码：599 / 606

页数：8

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