Interaction between amphiphilic peptides and phospholipid membranes

被引:127
|
作者
Stromstedt, Adam A. [1 ]
Ringstad, Lovisa [1 ]
Schmidtchen, Artur [2 ]
Malmsten, Martin [1 ]
机构
[1] Uppsala Univ, Dept Pharm, SE-75123 Uppsala, Sweden
[2] Lund Univ, Sect Dermatol & Venereol, Dept Clin Sci, SE-22184 Lund, Sweden
基金
瑞典研究理事会;
关键词
AMP; Antimicrobial peptide; Bacteria; Liposome; Membrane; HELICAL ANTIMICROBIAL PEPTIDES; HEPARIN-BINDING PEPTIDES; HEMOLYTIC-ACTIVITY; LIPID-BILAYERS; ANTIBACTERIAL PEPTIDES; STAPHYLOCOCCUS-AUREUS; ACTIVE PEPTIDE; LYTIC PEPTIDES; ATOMIC-FORCE; LL-37;
D O I
10.1016/j.cocis.2010.05.006
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
This brief review aims at providing some illustrative examples on the interaction between amphiphilic peptides and phospholipid membranes an area of significant current interest Focusing on antimicrobial peptides factors affecting peptide-membrane interactions are addressed including effects of peptide length charge hydrophobicity secondary structure and topology Effects of membrane composition are also illustrated including effects of membrane charge nature of the polar headgroup and presence of cholesterol and other sterols Throughout novel insights on the importance of peptide adsorption density on membrane stability are emphasized as is the correlation between peptide adsorption peptide induced leakage in model liposome systems peptide-induced lysis of bacteria and bacteria killing (C) 2010 Elsevier Ltd All rights reserved
引用
收藏
页码:467 / 478
页数:12
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