A self-assembled DNA nanostructure for targeted and pH-triggered drug delivery to combat doxorubicin resistance

被引：18

作者：

Liu, Juan ^{[1
,2
]}

Ma, Xiaowei ^{[1
,2
]}

Lei, Chunni ^{[1
,2
]}

Xue, Xiangdong ^{[1
,2
]}

Wei, Tuo ^{[1
,2
]}

Zhao, Jing ^{[3
]}

Li, Shuyi ^{[1
,2
]}

Liang, Xing-Jie ^{[1
,2
]}

机构：

[1] Natl Ctr Nanosci & Technol, Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China

[2] Natl Ctr Nanosci & Technol, Lab Controllable Nanopharmaceut, Beijing 100190, Peoples R China

[3] Hebei Med Univ, Dept Histol & Embryol, Shijiazhuang 050017, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 22期

基金：

北京市自然科学基金;

关键词：

CANCER; NANOPARTICLES; NUCLEOLIN; PLATFORM; THERAPY; TUMORS;

D O I：

10.1039/c6tb00761a

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

We developed a novel self-assembled DNA nanostructure for anticancer drug delivery. The resulting nanostructure was able to specifically target cancer cells and release the loaded drug at pH 5.0. More importantly, the drug-loaded DNA nanostructure effectively circumvented doxorubicin resistance of human lung adenocarcinoma epithelial cancer cells.

引用

收藏

页码：3854 / 3858

页数：5

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