Therapeutic uses for Angiotensin-(1-7)

被引：27

作者：

Machado-Silva, Alice ^{[1
]}

Passos-Silva, Danielle ^{[2
]}

Santos, Robson Augusto ^{[2
]}

Sinisterra, Ruben Dario ^{[3
]}

机构：

[1] Fundacao Oswaldo Cruz, CDTS, Rio De Janeiro, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Quim, Inst Ciencias Exatas, Belo Horizonte, MG, Brazil

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2016年 / 26卷 / 06期

关键词：

Angiotensin (1-7); Arg0; Mas receptor; PanCyte; TXA-127; RAS; IMPROVES LIPID-METABOLISM; ORAL FORMULATION; SKELETAL-MUSCLE; ENZYME; MAS; SYSTEM; BRAIN; INFLAMMATION; INHIBITION; PEPTIDE;

D O I：

10.1080/13543776.2016.1179283

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Introduction: Angiotensin-(1-7) is a key component of the Renin-Angiotensin System, which can counter-regulate several deleterious effects caused by angiotensin II. Due to the potential for therapeutic use, several of its actions are specifically described in patents. Areas covered: In this review, the authors describe a plethora of therapeutic uses for Angiotensin-(1-7), claimed and supported by experimental evidence in patent documents and applications. Expert opinion: The clinical potential of Angiotensin-(1-7) as a therapeutic agent to treat several pathologies is evidenced by the variety of patents and clinical trials involving this peptide. Cancer treatment is one of the most advanced therapeutic areas, but clinical studies are also available in several other areas, such as cardiovascular, hematological, transplantation, surgical and medical procedures.

引用

页码：669 / 678

页数：10

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