Four faces of cellular senescence

被引：1505

作者：

Rodier, Francis ^{[2
,3
]}

Campisi, Judith ^{[1
,4
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

[2] Univ Montreal, Inst Canc Montreal, Ctr Hosp, Res Ctr, Montreal, PQ H2L 4M1, Canada

[3] Univ Montreal, Dept Radiol Radio Oncol & Nucl Med, Montreal, PQ H3C 3J7, Canada

[4] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

来源：

JOURNAL OF CELL BIOLOGY | 2011年 / 192卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ONCOGENE-INDUCED SENESCENCE; DNA-DAMAGE RESPONSE; HISTONE DEACETYLASE INHIBITORS; HUMAN-DIPLOID FIBROBLASTS; LIFE-SPAN; IN-VIVO; REPLICATIVE SENESCENCE; HUMAN-CELLS; PREMATURE SENESCENCE; TRIGGERS SENESCENCE;

D O I：

10.1083/jcb.201009094

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular senescence is an important mechanism for preventing the proliferation of potential cancer cells. Recently, however, it has become apparent that this process entails more than a simple cessation of cell growth. In addition to suppressing tumorigenesis, cellular senescence might also promote tissue repair and fuel inflammation associated with aging and cancer progression. Thus, cellular senescence might participate in four complex biological processes (tumor suppression, tumor promotion, aging, and tissue repair), some of which have apparently opposing effects. The challenge now is to understand the senescence response well enough to harness its benefits while suppressing its drawbacks.

引用

收藏

页码：547 / 556

页数：10

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