New phenolic acids from Salvia yunnanensis CH Wright

被引：11

作者：

Yu, Yun ^{[1
]}

Wang, Yin-ru ^{[1
]}

Dong, Zhen-huan ^{[1
]}

Li, Wei ^{[2
]}

Li, Shu-Ming ^{[2
]}

Huang, Xue-feng ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing, Jiangsu, Peoples R China

[2] Tasly Pharmaceut Co Ltd, Tasly R&D Inst, Tianjin, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Salvia yunnanensis; phenolic acids; phenylpropanoids; neuroprotection; MILTIORRHIZA; POLYPHENOLS; DERIVATIVES; LIGNAN; L;

D O I：

10.1080/14786419.2017.1315577

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new phenolic acids, ethyl pro-lithospermate (1), n-butyl prolithospermate (2) were isolated from Salvia yunnanensis C.H. Wright, along with nineteen known compounds (3-21). The structures of the isolated compounds were elucidated on the basis of extensive spectrometry and by comparing their physical and spectroscopic data to the literature. Among them, compounds 11, 12 and 14-16 were firstly isolated from S. yunnanensis C.H. Wright. Some of the isolated compounds were evaluated for their neuroprotection. Compounds 10-12 showed significant neuroprotective effects in PC12 cells and compounds 1, 4-7 displayed moderate neuroprotective effects. [GRAPHICS] .

引用

页码：2505 / 2512

页数：8

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