Precise nanomedicine for intelligent therapy of cancer

被引：360

作者：

Chen, Huabing ^{[1
]}

Gu, Zhanjun ^{[2
]}

An, Hongwei ^{[2
,3
]}

Chen, Chunying ^{[3
,4
]}

Chen, Jie ^{[5
,6
,7
]}

Cui, Ran ^{[8
,9
]}

Chen, Siqin ^{[10
,11
]}

Chen, Weihai ^{[12
]}

Chen, Xuesi ^{[5
,6
,7
]}

Chen, Xiaoyuan ^{[13
]}

Chen, Zhuo ^{[14
]}

Ding, Baoquan ^{[3
]}

Dong, Qian ^{[14
]}

Fan, Qin ^{[15
]}

Fu, Ting ^{[14
]}

Hou, Dayong ^{[3
]}

Jiang, Qiao ^{[3
]}

Ke, Hengte ^{[1
]}

Jiang, Xiqun ^{[16
]}

Liu, Gang ^{[17
,18
]}

Li, Suping ^{[3
]}

Li, Tianyu ^{[19
]}

Liu, Zhuang ^{[15
]}

Nie, Guangjun ^{[3
]}

Ovais, Muhammad ^{[3
,4
]}

Pang, Daiwen ^{[8
,9
]}

Qiu, Nasha ^{[10
,11
]}

Shen, Youqing ^{[10
,11
]}

Tian, Huayu ^{[5
,6
,7
]}

Wang, Chao ^{[15
]}

Wang, Hao ^{[3
]}

Wang, Ziqi ^{[3
]}

Xu, Huaping ^{[19
]}

Xu, Jiang-Fei ^{[15
]}

Yang, Xiangliang ^{[20
]}

Zhu, Shuang ^{[2
]}

Zheng, Xianchuang ^{[16
]}

Zhang, Xianzheng ^{[12
]}

Zhao, Yanbing ^{[20
]}

Tan, Weihong ^{[14
,21
,22
,23
]}

Zhang, Xi ^{[19
]}

Zhao, Yuliang ^{[3
]}

机构：

[1] Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Dis, State Key Lab Radiat Med & Protect, Suzhou 215123, Peoples R China

[2] Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China

[3] Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[5] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China

[6] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China

[7] Jilin Biomed Polymers Engn Lab, Changchun 130022, Jilin, Peoples R China

[8] Wuhan Univ, Key Lab Analyt Chem Biol & Med, Minist Educ, Coll Chem & Mol Sci,State Key Lab Virol, Wuhan 430072, Hubei, Peoples R China

[9] Wuhan Univ, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China

[10] Zhejiang Univ, Ctr Bionanoengn, Hangzhou 310027, Zhejiang, Peoples R China

[11] Zhejiang Univ, Coll Chem & Biol Engn, Minist Educ, Key Lab Biomass Chem Engn, Hangzhou 310027, Zhejiang, Peoples R China

[12] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China

[13] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA

[14] Hunan Univ, Aptamer Engn Ctr Hunan Prov, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Mol Sci & Biomed Lab, Changsha 410082, Hunan, Peoples R China

[15] Soochow Univ, Inst Funct Nano & Soft Mat, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China

[16] Nanjing Univ, Coll Chem & Chem Engn, Dept Polymer Sci & Engn, Nanjing 210093, Jiangsu, Peoples R China

[17] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China

[18] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China

[19] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[20] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Hubei, Peoples R China

[21] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

[22] Univ Florida, Ctr Res Bionano Interface, Hlth Canc Ctr, Dept Physiol & Funct Genom,UF Genet Inst, Gainesville, FL 32611 USA

[23] Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA

来源：

SCIENCE CHINA-CHEMISTRY | 2018年 / 61卷 / 12期

基金：

中国国家自然科学基金;

关键词：

nanomedicine; nanoparticles; cancer therapy; cancer imaging; intelligent therapy; UP-CONVERSION-NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; AGGREGATION-INDUCED EMISSION; NEAR-INFRARED FLUORESCENCE; HUMAN SERUM-ALBUMIN; IN-VIVO EVALUATION; AG2S QUANTUM DOTS; TRIGGERED PHOTODYNAMIC THERAPY; BLACK PHOSPHORUS NANOPARTICLES; PROTEIN-BASED NANOPARTICLES;

D O I：

10.1007/s11426-018-9397-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

引用

页码：1503 / 1552

页数：50

共 700 条

[1] Self-Assembled Peptide- and Protein-Based Nanomaterials for Antitumor Photodynamic and Photothermal Therapy [J].