The Decline of Pneumococcal Resistance after Cessation of Mass Antibiotic Distributions for Trachoma

被引：76
作者：
Haug, Sara
Lakew, Takele [4 ]
Habtemariam, Gabremaskal [4 ]
Alemayehu, Wondu [4 ]
Cevallos, Vicky
Zhou, Zhaoxia
House, Jenafir
Ray, Kathryn
Porco, Travis [2 ,3 ]
Rutar, Tina
Keenan, Jeremy
Lietman, Thomas M. [2 ,3 ]
Gaynor, Bruce D. [1 ]
机构：
[1] Univ Calif San Francisco, Francis I Proctor Fdn, Dept Ophthalmol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Inst Global Hlth, San Francisco, CA 94143 USA
[4] ORBIS Int, New York, NY USA
来源：
CLINICAL INFECTIOUS DISEASES | 2010年 / 51卷 / 05期
关键词：
STREPTOCOCCUS-PNEUMONIAE; CHLAMYDIA-TRACHOMATIS; BLINDING TRACHOMA; AZITHROMYCIN; ELIMINATION; COMMUNITY;
D O I：
10.1086/655697
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
After 6 biannual mass distributions of oral azithromycin for trachoma in Ethiopian communities, 76.8% (95% confidence interval [CI], 66.3%-85.1%) of nasopharyngeal Streptococcus pneumoniae isolates from children aged 1-5 years were resistant to macrolides. Twelve and 24 months after the last azithromycin treatment, resistance decreased to 30.6% (95% CI, 18.8%-40.4%; P < .001) and 20.8% (95% CI, 12.7%-30.7%; P < .001), respectively. Macrolide resistance decreases after antibiotic pressure is removed.
引用
收藏
页码：571 / 574
页数：4
相关论文
共 16 条
[1]  
CLSI, 2009, M44S3 CLSI
[2]   Adverse and beneficial secondary effects of mass treatment with azithromycin to eliminate blindness due to trachoma in Nepal [J].
Fry, AM ;
Jha, HC ;
Lietman, TM ;
Chaudhary, JSP ;
Bhatta, RC ;
Elliott, J ;
Hyde, T ;
Schuchat, A ;
Gaynor, B ;
Dowell, SF .
CLINICAL INFECTIOUS DISEASES, 2002, 35 (04) :395-402
[3]   Topical ocular antibiotics induce bacterial resistance at extraocular sites [J].
Gaynor, BD ;
Chidambaram, JD ;
Cevallos, V ;
Miao, Y ;
Miller, K ;
Jha, HC ;
Bhatta, RC ;
Chaudhary, JSP ;
Holm, SO ;
Whitcher, JP ;
Holbrook, KA ;
Fry, AM ;
Lietman, TM .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2005, 89 (09) :1097-1099
[4]   Can blinding trachoma be eliminated by 20/20? [J].
Kumaresan, J .
EYE, 2005, 19 (10) :1067-1073
[5]   A prospective study of the impact of community-based azithromycin treatment of trachoma on carriage and resistance of Streptococcus pneumoniae [J].
Leach, AJ ;
ShelbyJames, TM ;
Mayo, M ;
Gratten, M ;
Laming, AC ;
Currie, BJ ;
Mathews, JD .
CLINICAL INFECTIOUS DISEASES, 1997, 24 (03) :356-362
[6]   Global elimination of trachoma: How frequently should we administer mass chemotherapy? [J].
Lietman, T ;
Porco, T ;
Dawson, C ;
Blower, S .
NATURE MEDICINE, 1999, 5 (05) :572-576
[7]   New steps toward eliminating blinding trachoma [J].
Mariotti, SP .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (19) :2004-2007
[8]   Feasibility of eliminating ocular Chlamydia trachomatis with repeat mass antibiotic treatments [J].
Melese, M ;
Chidambaram, JD ;
Alemayelm, W ;
Lee, DC ;
Yi, EH ;
Cevallos, V ;
Zhou, ZX ;
Donnellan, C ;
Saidel, M ;
Whitcher, JP ;
Gaynor, BD ;
Lietman, TM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 292 (06) :721-725
[9]   Comparison of annual and biannual mass antibiotic administration for elimination of infectious trachoma [J].
Melese, Muluken ;
Alemayehu, Wondu ;
Lakew, Takele ;
Yi, Elizabeth ;
House, Jenafir ;
Chidambaram, Jaya D. ;
Zhou, Zhaoxia ;
Cevallos, Vicky ;
Ray, Kathryn ;
Hong, Kevin Cyrus ;
Porco, Travis C. ;
Phan, Isabella ;
Zaidi, Ali ;
Gaynor, Bruce D. ;
Whitcher, John P. ;
Lietman, Thomas M. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (07) :778-784
[10]   Evaluation of a medium (STGG) for transport and optimal recovery of Streptococcus pneumoniae from nasopharyngeal secretions collected during field studies [J].
O'Brien, KL ;
Bronsdon, MA ;
Dagan, R ;
Yagupsky, P ;
Janco, J ;
Elliott, J ;
Whitney, CG ;
Yang, YH ;
Robinson, LGE ;
Schwartz, B ;
Carlone, GM .
JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (03) :1021-1024
12