The Decline of Pneumococcal Resistance after Cessation of Mass Antibiotic Distributions for Trachoma

被引：75

作者：

Haug, Sara

Lakew, Takele ^{[4
]}

Habtemariam, Gabremaskal ^{[4
]}

Alemayehu, Wondu ^{[4
]}

Cevallos, Vicky

Zhou, Zhaoxia

House, Jenafir

Ray, Kathryn

Porco, Travis ^{[2
,3
]}

Rutar, Tina

Keenan, Jeremy

Lietman, Thomas M. ^{[2
,3
]}

Gaynor, Bruce D. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Francis I Proctor Fdn, Dept Ophthalmol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Inst Global Hlth, San Francisco, CA 94143 USA

[4] ORBIS Int, New York, NY USA

来源：

CLINICAL INFECTIOUS DISEASES | 2010年 / 51卷 / 05期

关键词：

STREPTOCOCCUS-PNEUMONIAE; CHLAMYDIA-TRACHOMATIS; BLINDING TRACHOMA; AZITHROMYCIN; ELIMINATION; COMMUNITY;

D O I：

10.1086/655697

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

After 6 biannual mass distributions of oral azithromycin for trachoma in Ethiopian communities, 76.8% (95% confidence interval [CI], 66.3%-85.1%) of nasopharyngeal Streptococcus pneumoniae isolates from children aged 1-5 years were resistant to macrolides. Twelve and 24 months after the last azithromycin treatment, resistance decreased to 30.6% (95% CI, 18.8%-40.4%; P < .001) and 20.8% (95% CI, 12.7%-30.7%; P < .001), respectively. Macrolide resistance decreases after antibiotic pressure is removed.

引用

页码：571 / 574

页数：4

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