SLEEP-WAKEFULNESS IN ALCOHOL PREFERRING AND NON-PREFERRING RATS FOLLOWING BINGE ALCOHOL ADMINISTRATION

被引:17
作者
Thakkar, M. M. [1 ,2 ]
Engemann, S. C. [2 ]
Sharma, R. [2 ]
Mohan, R. R. [3 ]
Sahota, P. [2 ]
机构
[1] Univ Missouri, Harry S Truman Mem Vet Hosp, Dept Neurol, Columbia, MO 65201 USA
[2] Univ Missouri, Dept Neurol, Columbia, MO 65201 USA
[3] Univ Missouri, Mason Eye Inst, Columbia, MO 65201 USA
关键词
alcohol preferring P rats; wakefulness; NREM sleep; ethanol; REM sleep; CEREBRAL GLUCOSE-UTILIZATION; P RATS; ETHANOL EXPOSURE; BASAL FOREBRAIN; REPEATED DEPRIVATIONS; SEEKING BEHAVIOR; ANIMAL-MODELS; A1; RECEPTOR; NP RATS; LINES;
D O I
10.1016/j.neuroscience.2010.07.005
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The alcohol-preferring (P) rat is a valid animal model of alcoholism. However, the effect of alcohol on sleep in P or alcohol non-preferring (NP) rats is unknown. Since alcohol consumption has tremendous impact on sleep, the present study compared the effects of binge alcohol administration on sleep-wakefulness in P and NP rats. Using standard surgical procedures, the P and NP rats were bilaterally implanted with sleep recording electrodes. Following postoperative recovery and habituation, pre-ethanol (baseline) sleep-wakefulness was electrographically recorded for 48 h. Subsequently, ethanol was administered beginning with a priming dose of 5 g/Kg followed by two doses of 2 g/Kg every 8 h on the first day and three doses of 3 g/Kg/8 h on the second day. On the following day (post-ethanol), undisturbed sleep wakefulness was electrographically recorded for 24 h. Our initial results suggest that, during baseline conditions, the time spent in each of the three behavioral states: wakefulness, non-rapid eye movement (NREM) sleep and REM sleep, was comparable between P and NP rats. However, the P rats were more susceptible to changes in sleep-wakefulness following 2 days of binge ethanol treatment. As compared to NP rats, the P rats displayed insomnia like symptoms including a significant reduction in the amount of time spent in NREM sleep coupled with a significant increase in wakefulness on post-ethanol day. Subsequent analysis revealed that binge ethanol induced increased wakefulness and reduced NREM sleep in P rats occurred mainly in the dark period. This is the first study that: (1) demonstrates spontaneous sleep-wake profile in P and NP rats, and (2) compares the effects of binge ethanol treatment on sleep in P and NP rats. Our results suggest that, as compared to NP rats, the P rats were more susceptible to sleep disruptions after binge ethanol treatment. In addition, the P rats exhibited insomnia-like symptoms observed during abstinence from alcohol in human subjects. Published by Elsevier Ltd on behalf of IBRO.
引用
收藏
页码:22 / 27
页数:6
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