Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies

被引：96

作者：

Guedes, Joana R. ^{[1
,2
,3
,4
]}

Lao, Taotao ^{[4
]}

Cardoso, Ana L. ^{[3
]}

El Khoury, Joseph ^{[4
,5
]}

机构：

[1] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Doctoral Programme Expt Biol & Biomed, Coimbra, Portugal

[2] Univ Coimbra, Inst Interdisciplinary Res, Coimbra, Portugal

[3] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Coimbra, Portugal

[4] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Charlestown, MA 02129 USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, Div Infect Dis, Charlestown, MA 02129 USA

来源：

FRONTIERS IN NEUROLOGY | 2018年 / 9卷

关键词：

Alzheimer's disease; amyloid-beta peptide; protein tau; microglia; monocytes; chemokine receptors; chemokines; neuroinflammation; TRANSGENIC MOUSE MODEL; GENOME-WIDE ASSOCIATION; FRACTALKINE RECEPTOR; SCAVENGER RECEPTOR; COGNITIVE IMPAIRMENTS; IDENTIFIES VARIANTS; NEUROIMMUNE SYSTEM; UP-REGULATION; BLOOD-CELLS; BRAIN;

D O I：

10.3389/fneur.2018.00549

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chemokines and their receptors have been shown to affect amyloid-beta (A beta) and tau pathologies in mouse models of Alzheimer's disease (AD) by regulating microglia and monocyte-associated neuroinflammation, microglial movement and monocyte recruitment into the brain. These cells in turn can promote and mediate Ab phagocytosis and degradation and tau phosphorylation. In this review we discuss published work in this field in mouse models of AD and review what is known about the contributions of microglial and monocyte chemokines and their receptors to amyloid and tau pathologies. We focus on the roles of the chemokine/chemokine receptor pairs CCL2/CCR2, CX3CL1/CX3CR1, CCL5/CCR5, CXCL10/CXCR3 and CXCL1/CXCR2, highlighting important knowledge gaps in this field. A full understanding of the functions of chemokines and their receptors in AD may guide the development of novel immunotherapies for this devastating disease.

引用

页数：8

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