Stimulus responsive peptide based materials

被引:276
作者
Lowik, Dennis W. P. M. [1 ]
Leunissen, E. H. P. [1 ]
van den Heuvel, M. [1 ]
Hansen, M. B. [1 ]
van Hest, Jan C. M. [1 ]
机构
[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands
关键词
ELASTIN-LIKE POLYPEPTIDE; HELICAL COILED-COILS; BETA-SHEET; AMPHIPHILE NANOFIBERS; SECONDARY STRUCTURE; AMYLOID FORMATION; DESIGNED PEPTIDE; ALPHA-HELIX; METAL CLIPS; PH;
D O I
10.1039/b914342b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this tutorial review we give an introduction into the field of stimulus responsive peptide based materials illustrated by some recent and current developments. We have tried to categorize them according to the stimulus the materials are responsive to, being pH, temperature, metal ions, enzymes and light. Because we have focused on the structural changes that these stimuli effect we have further classified the topics according to the secondary structures that are involved. These changes in molecular structure in turn cause a change in the macroscopic properties of the material they constitute. It is believed that these materials, often referred to as smart materials, have a great potential being applicable in areas like drug delivery, tissue engineering and bio-sensors.
引用
收藏
页码:3394 / 3412
页数:19
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