Human nonsense-mediated RNA decay regulates EMT by targeting the TGF-ss signaling pathway in lung adenocarcinoma

被引：38

作者：

Cao, Lu ^{[1
]}

Qi, Lisha ^{[1
]}

Zhang, Lin ^{[2
]}

Song, Wangzhao ^{[1
]}

Yu, Yue ^{[3
]}

Xu, Cong ^{[1
]}

Li, Lingmei ^{[1
]}

Guo, Yuhong ^{[1
]}

Yang, Lingyi ^{[1
]}

Liu, Changxu ^{[1
]}

Huang, Qiujuan ^{[1
]}

Wang, Yalei ^{[1
]}

Sun, Baocun ^{[1
]}

Meng, Bin ^{[1
]}

Zhang, Bin ^{[3
]}

Cao, Wenfeng ^{[1
]}

机构：

[1] Tianjin Med Univ, Tianjin Med Univ Canc Inst & Hosp,Dept Pathol, Natl Clin Res Ctr Canc,Tianjins Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy,Minist Educ, Tianjin 300060, Peoples R China

[2] Tianjin Cent Hosp Gynecol Obstet, Dept Pathol, Tianjin 300060, Peoples R China

[3] Tianjin Med Univ, Tianjin Med Univ Canc Inst & Hosp,Dept Breast Can, Natl Clin Res Ctr Canc,Tianjins Clin Res Ctr Canc, Key Lab Breast Canc Prevent & Therapy,Minist Educ, Tianjin 300060, Peoples R China

来源：

CANCER LETTERS | 2017年 / 403卷

基金：

中国国家自然科学基金;

关键词：

Nonsense-mediated mRNA decay; UPF1; EMT; TGF-ss; Lung adenocarcinoma; EPITHELIAL-MESENCHYMAL TRANSITION; MESSENGER-RNA; CANCER CELLS; EXPRESSION; UPF1; PROGRESSION; IMPACT; RULES; GENES; BETA;

D O I：

10.1016/j.canlet.2017.06.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nonsense-mediated mRNA decay (NMD) is a highly conserved pathway that selectively degrades aberrant RNA transcripts. In this study, we proved that NMD regulates the epithelial-mesenchymal transition (EMT) of lung adenocarcinoma (ADC). Moreover, we found that NMD core factor UP-frameshift 1 tends to be expressed at lower levels in human ADC tissues than in normal lung tissues, thereby raising the possibility that NMD may be downregulated to permit ADC oncogenesis. Our experiments in human ADC cell lines showed that downregulating NMD can promote EMT. Moreover, EMT can be inhibited by upregulating NMD. We tested the role of TGF-ss signaling and found that NMD influences EMT by targeting the TGF-ss signaling pathway. Our findings reveal that NMD is a potential tumor regulatory mechanism and may be a potential therapeutic target for ADC. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：246 / 259

页数：14

共 49 条

[1] The human RNA surveillance factor UPF1 is required for S phase progression and genome stability [J].