Engineering of Nebulized Metal-Phenolic Capsules for Controlled Pulmonary Deposition

被引：61

作者：

Ju, Yi ^{[1
,2
]}

Cortez-Jugo, Christina ^{[1
,2
]}

Chen, Jingqu ^{[1
,2
]}

Wang, Ting-Yi ^{[3
]}

Mitchell, Andrew J. ^{[4
]}

Tsantikos, Evelyn ^{[5
]}

Bertleff-Zieschang, Nadja ^{[1
,2
]}

Lin, Yu-Wei ^{[6
]}

Song, Jiaying ^{[1
,2
]}

Cheng, Yizhe ^{[1
,2
]}

Mettu, Srinivas ^{[2
,7
]}

Rahim, Md Arifur ^{[1
,2
]}

Pan, Shuaijun ^{[1
,2
]}

Yun, Gyeongwon ^{[1
,2
]}

Hibbs, Margaret L. ^{[5
]}

Yeo, Leslie Y. ^{[8
]}

Hagemeyer, Christoph E. ^{[3
]}

Caruso, Frank ^{[1
,2
]}

机构：

[1] Univ Melbourne, ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Dept Chem Engn, Parkville, Vic 3010, Australia

[3] Monash Univ, Cent Clin Sch, Australian Ctr Blood Dis, Nanobiotechnol Lab, Melbourne, Vic 3004, Australia

[4] Univ Melbourne, Dept Chem Engn, Mat Characterisat & Fabricat Platform, Parkville, Vic 3010, Australia

[5] Monash Univ, Cent Clin Sch, Dept Immunol & Pathol, Melbourne, Vic 3004, Australia

[6] Monash Univ, Dept Microbiol, Monash Biomed Inst, Clayton, Vic 3800, Australia

[7] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia

[8] RMIT Univ, Sch Engn, Micro Nanophys Res Lab, Melbourne, Vic 3001, Australia

来源：

ADVANCED SCIENCE | 2020年 / 7卷 / 06期

基金：

澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

aerodynamic diameter; capsules; metal-phenolic networks; nebulization; pulmonary delivery; DRUG-DELIVERY; INHALATION TREATMENT; TARGETED DELIVERY; NANOPARTICLES; IMPACTOR; PARTICLES; DISEASE; ACID;

D O I：

10.1002/advs.201902650

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Particle-based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the efficacy of encapsulated inhaled drugs. This study describes the nanoengineering and nebulization of metal-phenolic capsules as pulmonary carriers of small molecule drugs and macromolecular drugs in lung cell lines, a human lung model, and mice. Tuning the aerodynamic diameter by increasing the capsule shell thickness (from approximate to 100 to 200 nm in increments of approximate to 50 nm) through repeated film deposition on a sacrificial template allows precise control of capsule deposition in a human lung model, corresponding to a shift from the alveolar region to the bronchi as aerodynamic diameter increases. The capsules are biocompatible and biodegradable, as assessed following intratracheal administration in mice, showing >85% of the capsules in the lung after 20 h, but <4% remaining after 30 days without causing lung inflammation or toxicity. Single-cell analysis from lung digests using mass cytometry shows association primarily with alveolar macrophages, with >90% of capsules remaining nonassociated with cells. The amenability to nebulization, capacity for loading, tunable aerodynamic properties, high biocompatibility, and biodegradability make these capsules attractive for controlled pulmonary delivery.

引用

页数：13

共 73 条

[71]

Yang Y.-L., 2017, J CELL DEATH DIS, V8, pe2625

[72] Advanced Therapeutic Strategies for Chronic Lung Disease Using Nanoparticle-Based Drug Delivery [J].