Alterations of the expression levels of CPT-1, SCD1, TRβ-1 and related microRNAs are involved in lipid metabolism impairment in adult rats caused by maternal coconut oil intake during breastfeeding

被引：3

作者：

Quitete, Fernanda Torres ^{[1
]}

de Moura, Egberto Gaspar ^{[1
]}

Peixoto, Thamara Cherem ^{[1
]}

Torsoni, Adriana Souza ^{[2
]}

Torsoni, Marcio Alberto ^{[2
]}

Milanski, Marciane ^{[2
]}

Ignacio-Souza, Leticia M. ^{[2
]}

Simino, Lais Angelica ^{[2
]}

de Oliveira, Elaine ^{[1
]}

Lisboa, Patricia Cristina ^{[1
]}

机构：

[1] Univ Estado Rio De Janeiro, Roberto Alcantara Gomes Biol Inst, Dept Physiol Sci, BR-20551030 Rio De Janeiro, RJ, Brazil

[2] Univ Estadual Campinas, Sch Appl Sci, Lab Metab Disorders, BR-13484350 Limeira, SP, Brazil

来源：

JOURNAL OF FUNCTIONAL FOODS | 2019年 / 63卷

关键词：

Coconut oil; Metabolic programming; Obesity; Thyroid function; Lipid metabolism; MicroRNA; GENE-EXPRESSION; THYROID-HORMONE; ADIPOSE-TISSUE; FLAXSEED OIL; BODY-WEIGHT; LACTATION; OBESITY; DIET; FAT;

D O I：

10.1016/j.jff.2019.103577

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

We studied the molecular and epigenetic mechanisms associated with dysfunctions caused by postnatal coconut oil exposure. Lactating dams were divided into soybean oil (SO) and coconut oil (CO) groups (0.5 g/kg/gavage). Half of the CO offspring received CO in their chow throughout their lifetime (CO + C). Adult CO offspring had higher liver TR beta-1 mRNA, which is consistent with lower miR-181a and lower DIO2 mRNA in brown adipose tissue (BAT) and higher CPT-1 mRNA in white adipose tissue (WAT). CO + C offspring exhibited higher BAT miR-382*, but DIO2 was unaltered. This group also had higher liver SCD1, miR-122 expression, and WAT SCD1 mRNA. CO and CO + C offspring had lower hepatic CPT-1 mRNA. The disturbances in CO offspring may be partially attributed to alterations in the enzymes involved in lipid metabolism, which may be mediated via mechanisms associated with miR-122. Continuous exposure to CO prohibits some of these changes.

引用

页数：8