Protein Expression of MMP-2 and MT1-MMP in Actinic Keratosis, Squamous Cell Carcinoma of the Skin, and Basal Cell Carcinoma
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作者:
Poswar, Fabiano de Oliveira
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Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, BrazilUniv Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
Poswar, Fabiano de Oliveira
[1
]
de Carvalho Fraga, Carlos Alberto
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Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, BrazilUniv Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
de Carvalho Fraga, Carlos Alberto
[1
]
Batista Gomes, Emisael Stenio
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Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, BrazilUniv Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
Batista Gomes, Emisael Stenio
[1
]
Farias, Lucyana Conceicao
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Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, BrazilUniv Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
Farias, Lucyana Conceicao
[1
]
Figueiredo Souza, Linton Wallis
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Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, BrazilUniv Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
Figueiredo Souza, Linton Wallis
[1
]
Souza Santos, Sergio Henrique
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Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
Univ Fed Minas Gerais, Belo Horizonte, MG, BrazilUniv Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
Souza Santos, Sergio Henrique
[1
,2
]
Gomez, Ricardo Santiago
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Univ Fed Minas Gerais, Belo Horizonte, MG, BrazilUniv Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
Gomez, Ricardo Santiago
[2
]
Batista de-Paula, Alfredo Mauricio
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Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, BrazilUniv Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
Batista de-Paula, Alfredo Mauricio
[1
]
Sena Guimaraes, Andre Luiz
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Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, BrazilUniv Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
Sena Guimaraes, Andre Luiz
[1
]
机构:
[1] Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
[2] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil
Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are 2 skin neoplasms with distinct potentials to invasion and metastasis. Actinic keratosis (AK) is a precursor lesion of SCC. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MT1-MMP in samples of BCC (n = 29), SCC (n = 12), and AK (n = 13). The ratio of positive cells to total cells was used to quantify the staining. Statistical significance was considered under the level P <.05. We found a higher expression of MMP-2 in tumor stroma and parenchyma of SCC as compared to BCC. The expression of this protein was also similar between SCC and its precursor actinic keratosis, and it was higher in the stroma of high-risk BCC when compared to low-risk BCC. MT1-MMP, which is an activator of MMP-2, was similarly expressed in all groups. Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in SCC and BCC.
机构:
Stanford Univ, Program Epithelial Biol, Dept Dermatol, Stanford, CA 94305 USAStanford Univ, Program Epithelial Biol, Dept Dermatol, Stanford, CA 94305 USA
机构:
Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Souza, Ludmilla R.
Fonseca-Silva, Thiago
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Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Fonseca-Silva, Thiago
Pereira, Camila S.
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Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Pereira, Camila S.
Santos, Erivelton P.
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Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Santos, Erivelton P.
Lima, Lucianne C.
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Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Lima, Lucianne C.
Carvalho, Heloisa A.
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Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Carvalho, Heloisa A.
Gomez, Ricardo S.
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Univ Fed Minas Gerais, Sch Dent, Dept Clin Pathol & Surg, Belo Horizonte, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Gomez, Ricardo S.
Guimaraes, Andre L. S.
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Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Guimaraes, Andre L. S.
De Paula, Alfredo M. B.
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Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
机构:
Stanford Univ, Program Epithelial Biol, Dept Dermatol, Stanford, CA 94305 USAStanford Univ, Program Epithelial Biol, Dept Dermatol, Stanford, CA 94305 USA
机构:
Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Souza, Ludmilla R.
Fonseca-Silva, Thiago
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Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Fonseca-Silva, Thiago
Pereira, Camila S.
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h-index: 0
机构:
Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Pereira, Camila S.
Santos, Erivelton P.
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Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Santos, Erivelton P.
Lima, Lucianne C.
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Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Lima, Lucianne C.
Carvalho, Heloisa A.
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机构:
Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Carvalho, Heloisa A.
Gomez, Ricardo S.
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机构:
Univ Fed Minas Gerais, Sch Dent, Dept Clin Pathol & Surg, Belo Horizonte, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Gomez, Ricardo S.
Guimaraes, Andre L. S.
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Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil
Guimaraes, Andre L. S.
De Paula, Alfredo M. B.
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Univ Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, BrazilUniv Estadual Montes Claros, Hlth Sci Programme, Montes Claros, MG, Brazil