Protein Expression of MMP-2 and MT1-MMP in Actinic Keratosis, Squamous Cell Carcinoma of the Skin, and Basal Cell Carcinoma

被引:18
作者
Poswar, Fabiano de Oliveira [1 ]
de Carvalho Fraga, Carlos Alberto [1 ]
Batista Gomes, Emisael Stenio [1 ]
Farias, Lucyana Conceicao [1 ]
Figueiredo Souza, Linton Wallis [1 ]
Souza Santos, Sergio Henrique [1 ,2 ]
Gomez, Ricardo Santiago [2 ]
Batista de-Paula, Alfredo Mauricio [1 ]
Sena Guimaraes, Andre Luiz [1 ]
机构
[1] Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil
[2] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil
关键词
basal cell carcinoma; squamous cell carcinoma; actinic keratosis; membrane-type matrix metalloproteinase-1; matrix metalloproteinase-2; MATRIX METALLOPROTEINASES; DIFFERENTIAL EXPRESSION; TUMOR INVASION; CANCER; MEMBRANE; TISSUE;
D O I
10.1177/1066896914540998
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are 2 skin neoplasms with distinct potentials to invasion and metastasis. Actinic keratosis (AK) is a precursor lesion of SCC. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MT1-MMP in samples of BCC (n = 29), SCC (n = 12), and AK (n = 13). The ratio of positive cells to total cells was used to quantify the staining. Statistical significance was considered under the level P <.05. We found a higher expression of MMP-2 in tumor stroma and parenchyma of SCC as compared to BCC. The expression of this protein was also similar between SCC and its precursor actinic keratosis, and it was higher in the stroma of high-risk BCC when compared to low-risk BCC. MT1-MMP, which is an activator of MMP-2, was similarly expressed in all groups. Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in SCC and BCC.
引用
收藏
页码:20 / 25
页数:6
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