Protein Expression of MMP-2 and MT1-MMP in Actinic Keratosis, Squamous Cell Carcinoma of the Skin, and Basal Cell Carcinoma

被引：18

作者：

Poswar, Fabiano de Oliveira ^{[1
]}

de Carvalho Fraga, Carlos Alberto ^{[1
]}

Batista Gomes, Emisael Stenio ^{[1
]}

Farias, Lucyana Conceicao ^{[1
]}

Figueiredo Souza, Linton Wallis ^{[1
]}

Souza Santos, Sergio Henrique ^{[1
,2
]}

Gomez, Ricardo Santiago ^{[2
]}

Batista de-Paula, Alfredo Mauricio ^{[1
]}

Sena Guimaraes, Andre Luiz ^{[1
]}

机构：

[1] Univ Estadual Montes Claros, BR-39401001 Montes Claros, MG, Brazil

[2] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2015年 / 23卷 / 01期

关键词：

basal cell carcinoma; squamous cell carcinoma; actinic keratosis; membrane-type matrix metalloproteinase-1; matrix metalloproteinase-2; MATRIX METALLOPROTEINASES; DIFFERENTIAL EXPRESSION; TUMOR INVASION; CANCER; MEMBRANE; TISSUE;

D O I：

10.1177/1066896914540998

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are 2 skin neoplasms with distinct potentials to invasion and metastasis. Actinic keratosis (AK) is a precursor lesion of SCC. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MT1-MMP in samples of BCC (n = 29), SCC (n = 12), and AK (n = 13). The ratio of positive cells to total cells was used to quantify the staining. Statistical significance was considered under the level P <.05. We found a higher expression of MMP-2 in tumor stroma and parenchyma of SCC as compared to BCC. The expression of this protein was also similar between SCC and its precursor actinic keratosis, and it was higher in the stroma of high-risk BCC when compared to low-risk BCC. MT1-MMP, which is an activator of MMP-2, was similarly expressed in all groups. Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in SCC and BCC.

引用

页码：20 / 25

页数：6

共 28 条

[1] The epidemiology of UV induced skin cancer
Armstrong, BK
Kricker, A
[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2001, 63 (1-3) : 8 - 18
[2] Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain
Basu, B.
de Sampaio, P. Correa
Mohammed, H.
Fogarasi, M.
Corrie, P.
Watkins, N. A.
Smethurst, P. A.
English, W. R.
Ouwehand, W. H.
Murphy, G.
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2012, 44 (02) : 393 - 403
[3] Insights into the Activity, Differential Expression, Mutual Regulation, and Functions of Matrix Metalloproteinases and A Disintegrin and Metalloproteinases in Hypertension and Cardiac Disease
Berry, Evan
Bosonea, Ana-Maria
Wang, Xiang
Fernandez-Patron, Carlos
[J]. JOURNAL OF VASCULAR RESEARCH, 2013, 50 (01) : 52 - 68
[4] Squamous-cell ephthelioma of the skin - A study of 256 cases
Broders, AC
[J]. ANNALS OF SURGERY, 1921, 73 : 141 - 160
[5] Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling
Brouxhon, S. M.
Kyrkanides, S.
Teng, X.
Athar, M.
Ghazizadeh, S.
Simon, M.
O'Banion, M. K.
Ma, L.
[J]. ONCOGENE, 2014, 33 (02) : 225 - 235
[6] Bryne M, 1998, Oral Dis, V4, P70
[7] Curran S, 1999, J PATHOL, V189, P300, DOI 10.1002/(SICI)1096-9896(199911)189:3<300::AID-PATH456>3.0.CO
[8] 2-C
[9] Dumas V, 1999, ANTICANCER RES, V19, P2929
[10] Metalloproteinase-2 expression correlates with aggressiveness of cutaneous squamous cell carcinomas
Fundyler, O
Khanna, M
Smoller, BR
[J]. MODERN PATHOLOGY, 2004, 17 (05) : 496 - 502

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