Risk factors for Age-related Macular Degeneration in a Greek population: The Thessaloniki Eye Study

被引:6
作者
Anastasopoulos, Eleftherios [1 ]
Haidich, Anna Bettina [2 ]
Coleman, Anne Louise [3 ]
Wilson, M. Roy [4 ]
Harris, Alon [5 ]
Yu, Fei [6 ]
Koskosas, Archimides [1 ]
Pappas, Theofanis [1 ]
Keskini, Christina [1 ]
Kalouda, Pelagia [1 ]
Karkamanis, Georgia [1 ]
Topouzis, Fotis [1 ]
机构
[1] Aristotle Univ Thessaloniki, Sch Med, Dept Ophthalmol, Lab Res & Clin Applicat Ophthalmol LARCAO, Thessaloniki, Greece
[2] Aristotle Univ Thessaloniki, Sch Med, Dept Epidemiol, Thessaloniki, Greece
[3] Univ Calif Los Angeles, David Geffen Sch Med, Stein Eye Inst, Los Angeles, CA 90095 USA
[4] Wayne State Univ, Detroit, MI USA
[5] Indiana Univ Sch Med, Dept Ophthalmol, Eugene & Marilyn Glick Eye Inst, Indianapolis, IN 46202 USA
[6] UCLA, Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA USA
关键词
Age-related macular degeneration; risk factors; Thessaloniki Eye study; Greek population; afternoon nap; LONG-TERM INCIDENCE; OPEN-ANGLE GLAUCOMA; ANGELES LATINO EYE; BLUE MOUNTAINS EYE; MARITAL-STATUS; CATARACT-SURGERY; BLOOD-PRESSURE; SUNLIGHT EXPOSURE; POOLED FINDINGS; SLEEP DURATION;
D O I
10.1080/09286586.2018.1512634
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To assess the association of potential risk factors with early and late age-related macular degeneration (AMD) in the Thessaloniki Eye Study (TES) population Design: Population-based, cross-sectional study of subjects over age of 60 living in Thessaloniki, Greece Methods: Subjects without any AMD features and subjects with early and late AMD (neovascular AMD or geographic atrophy) were identified in the TES cohort using standardized procedures and masked grading of stereo color fundus photos. Demographic, lifestyle, systemic and other ophthalmic covariates were also collected during a detailed examination process. Their association with AMD was investigated using univariate and multivariate adjusted logistic regression models. Results: Among the 2108 participants with gradable photos, the grading process identified 1204 subjects with no AMD, 848 subjects with early AMD, and 56 subjects with late AMD (24 with geographic atrophy and 32 with neovascular AMD). In multivariate analysis, compared to no AMD, late AMD was positively associated with older age (OR:1.16; 95%CI:1.10-1.22 per year of age), current smoking (smoking vs. never smoking, OR:2.34; 95%CI:1.12-4.90), prior cataract surgery (cataract surgery vs. no cataract surgery OR:2.06; 95%CI:0.96-4.40), marital status (divorced/separated vs. married, OR:3.10; 95%CI:1.08-8.93) and with 60% lower odds when sleeping in the afternoon (yes vs. no, OR:0.40; 95%CI:0.22-0.72). Early AMD was positively associated with older age (OR: 1.03; 95%CI:1.01-1.05 per year of age) and negatively with higher pulse pressure (OR:0.99; 95%CI:0.98-0.99 per mmHg). Conclusions: In TES, apart for well-known risk factors for AMD like age, smoking, and cataract surgery, two novel behavioral risk factors for prevalent late AMD were suggested. Sleeping in the afternoon was associated with 60% decreased odds for late AMD and 67% decreased odds for neovascular AMD. Being divorced/separated compared to married was associated with 3-fold higher odds for late AMD. Large longitudinal population-based studies will be necessary to further establish the potential late AMD risk effects of these two novel factors, to demonstrate potential implications of underlying pathogenetic mechanisms, and to explore preventive measures and therapeutic targets.
引用
收藏
页码:457 / 469
页数:13
相关论文
共 64 条
[1]   Characteristics of Pseudoexfoliation in the Thessaloniki Eye Study [J].
Anastasopoulos, Eleftherios ;
Topouzis, Fotis ;
Wilson, M. Roy ;
Harris, Alon ;
Pappas, Theofanis ;
Yu, Fei ;
Koskosas, Archimidis ;
Founti, Panayiota ;
Coleman, Anne L. .
JOURNAL OF GLAUCOMA, 2011, 20 (03) :160-166
[2]  
[Anonymous], BMI CLASSIFICATION
[3]   Effect of marriage on duration of chest pain associated with acute myocardial infarction before seeking care [J].
Atzema, Clare L. ;
Austin, Peter C. ;
Huynh, Thao ;
Hassan, Ansar ;
Chiu, Maria ;
Wang, Julie T. ;
Tu, Jack V. .
CANADIAN MEDICAL ASSOCIATION JOURNAL, 2011, 183 (13) :1482-1491
[4]   Social and demographic predictors of no transport prior to premature cardiac death: United States 1999-2000 [J].
Barnett E. ;
Reader S. ;
Ward B.G. ;
Casper M.L. .
BMC Cardiovascular Disorders, 6 (1)
[5]   AN INTERNATIONAL CLASSIFICATION AND GRADING SYSTEM FOR AGE-RELATED MACULOPATHY AND AGE-RELATED MACULAR DEGENERATION [J].
BIRD, AEC ;
BRESSLER, NM ;
BRESSLER, SB ;
CHISHOLM, IH ;
COSCAS, G ;
DAVIS, MD ;
DEJONG, PTVM ;
KLAVER, CCW ;
KLEIN, BEK ;
KLEIN, R ;
MITCHELL, P ;
SARKS, JP ;
SARKS, SH ;
SOURBANE, G ;
TAYLOR, HR ;
VINGERLING, JR .
SURVEY OF OPHTHALMOLOGY, 1995, 39 (05) :367-374
[6]  
Bressler NM, 2003, ARCH OPHTHALMOL-CHIC, V121, P1621
[7]   Evening ambient light exposure can reduce circadian phase advances to morning light independent of sleep deprivation [J].
Burgess, Helen J. .
JOURNAL OF SLEEP RESEARCH, 2013, 22 (01) :83-88
[8]   Smoking, Cardiovascular Risk Factors, and Age-related Macular Degeneration in Asians: The Singapore Malay Eye Study [J].
Cackett, Peter ;
Wong, Tien Y. ;
Aung, Tin ;
Saw, Seang-Mei ;
Tay, Wan Ting ;
Rochtchina, Elena ;
Mitchell, Paul ;
Wang, Jie Jin .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2008, 146 (06) :960-967
[9]  
Campos Costa Ines, 2013, Am J Neurodegener Dis, V2, P228
[10]  
Casten Robin J, 2004, Curr Opin Ophthalmol, V15, P181, DOI 10.1097/01.icu.0000120710.35941.3f