Hyaluronan metabolism in remodeling extracellular matrix: probes for imaging and therapy of breast cancer

被引：31

作者：

Veiseh, M. ^{[1
]}

Turley, E. A. ^{[2
,3
]}

机构：

[1] Lawrence Berkeley Natl Labs, Div Life Sci, Berkeley, CA 94629 USA

[2] Univ Western Ontario, Dept Oncol, London Reg Canc Program, London Hlth Sci Ctr, London, ON, Canada

[3] Univ Western Ontario, Dept Biochem, London, ON, Canada

来源：

INTEGRATIVE BIOLOGY | 2011年 / 3卷 / 04期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; GENE-EXPRESSION SIGNATURES; ACUTE MYELOID-LEUKEMIA; IN-VIVO; MULTIPLE-MYELOMA; MALIGNANT BREAST; MACROMOLECULAR THERAPEUTICS; TUMOR MICROENVIRONMENT; ANTITUMOR BIOCONJUGATE; PEPTIDE VACCINATION;

D O I：

10.1039/c0ib00096e

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Clinical and experimental evidence increasingly support the concept of cancer as a disease that emulates a component of wound healing, in particular abnormal stromal extracellular matrix remodeling. Here we review the biology and function of one remodeling process, hyaluronan (HA) metabolism, which is essential for wound resolution but closely linked to breast cancer (BCA) progression. Components of the HA metabolic cycle (HAS2, SPAM1 and HA receptors CD44, RHAMM/HMMR and TLR2) are discussed in terms of their known functions in wound healing and in breast cancer progression. Finally, we discuss recent advances in the use of HA-based platforms for developing nanoprobes to image areas of active HA metabolism and for therapeutics in breast cancer.

引用

页码：304 / 315

页数：12

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