[11C]choline-PET-guided helical tomotherapy and estramustine in a patient with pelvic-recurrent prostate cancer: local control and toxicity profile after 24 months

被引:10
作者
Alongi, Filippo [1 ,2 ,3 ]
Schipani, Stefano [1 ]
Gajate, Ana Maria Samanes [4 ]
Rosso, Alberto [1 ]
Cozzarini, Cesare [1 ]
Fiorino, Claudio
Alongi, Pierpaolo [5 ]
Picchio, Maria [4 ]
Gianolli, Luigi [4 ]
Messa, Cristina [6 ]
Di Muzio, Nadia [1 ]
机构
[1] Ist Sci San Raffaele, Dept Radiotherapy, I-20132 Milan, Italy
[2] CNR, Ist Bioimmagini & Fisiol Mol, I-20133 Milan, Italy
[3] Hosp San Raffaele G Giglio, LATO, Cefalu, Italy
[4] Ist Sci San Raffaele, Dept Nucl Med, I-20132 Milan, Italy
[5] Univ Palermo, Med & Surg Sch, Palermo, Italy
[6] Milano Bicocca Univ, Monza, Italy
来源
TUMORI JOURNAL | 2010年 / 96卷 / 04期
关键词
C-11]choline-PET; tomotherapy; prostate; relapse; lymph node; SIMULTANEOUS INTEGRATED BOOST; RADIOTHERAPY; LYMPHADENECTOMY; METASTASES; THERAPY; RISK;
D O I
10.1177/030089161009600416
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[C-11]choline positron emission tomograhy can be useful to detect metastatic disease and to localize isolated lymph node relapse after primary treatment in case of prostate-specific antigen failure. In case of lymph node failure in prostate cancer patients, surgery or radiotherapy can be proposed with a curative intent. Some reports have suggested that radiotherapy could have a role in local control of oligometastatic lymph node disease. This is the first reported case of [C-11] choline positron emission tomography-guided helical tomotherapy concomitant with estramustine for the treatment of pelvic-recurrent prostate cancer. At 24 months after the end of helical tomotherapy, prostate-specific antigen was undetectable and no late toxicities were recorded. A disease-free survival of 24 months, in the absence of any type of systemic therapy, is uncommon in metastatic prostate cancer. The therapeutic approach of the case report is discussed and a literature review on the issue is presented.
引用
收藏
页码:613 / 617
页数:5
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