Benefit and a possible risk of tocilizumab therapy for adult-onset Still's disease accompanied by macrophage-activation syndrome

被引：87

作者：

Kobayashi, Masafumi ^{[1
]}

Takahashi, Yuko ^{[1
]}

Yamashita, Hiroyuki ^{[1
]}

Kaneko, Hiroshi ^{[1
]}

Mimori, Akio ^{[1
]}

机构：

[1] Natl Ctr Global Med, Div Rheumat Dis, Shinjuku Ku, Tokyo 1628655, Japan

来源：

MODERN RHEUMATOLOGY | 2011年 / 21卷 / 01期

关键词：

Adult-onset Still's disease; Tocilizumab; Macrophage-activation syndrome; Hemophagocytic lymphohistiocytosis; REACTIVE HEMOPHAGOCYTIC SYNDROME; JUVENILE IDIOPATHIC ARTHRITIS; RHEUMATOID-ARTHRITIS; RECEPTOR ANTIBODY; IL-6; RECEPTOR; DOUBLE-BLIND; MANAGEMENT; INTERLEUKIN-6; CHILDREN; PATIENT;

D O I：

10.1007/s10165-010-0348-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 57-year-old female case of intractable adult-onset Still's disease (AOSD). Initial high-dose prednisolone therapy was ineffective, and macrophage-activation syndrome (MAS) manifested after one session of additional tocilizumab therapy. After successful treatment for MAS with lipo-dexamethasone and cyclosporin, tocilizumab therapy aided in the rapid reduction of the therapeutic steroid dose. Tocilizumab may be useful for maintenance therapy for AOSD, although its efficacy is unclear for the highly active phase of the disease.

引用

页码：92 / 96

页数：5

共 35 条

[1]

Amenomori A, 2005, CLIN EXP RHEUMATOL, V23, P100

[2] Reactive haemophagocytic syndrome in adult-onset Still's disease: a report of six patients and a review of the literature [J].

Arlet, J.-B. ;

Huong, D. Le Thi ;

Marinho, A. ;

Amoura, Z. ;

Wechsler, B. ;

Papo, T. ;

Piette, J-C .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (12) :1596-1601

[3] Successful treatment of refractory adult still's disease and membranous glomerulonephritis with infliximab [J].

Babacan, Taner ;

Onat, Ahmet Mesut ;

Pehlivan, Yavuz ;

Comez, Gazi ;

Karakok, Metin .

CLINICAL RHEUMATOLOGY, 2010, 29 (04) :423-426

[4] Macrophage activation syndrome in rheumatic disease: What is the role of the antigen presenting cell? [J].

Behrens, Edward M. .

AUTOIMMUNITY REVIEWS, 2008, 7 (04) :305-308

[5] New advances in the management of juvenile idiopathic arthritis-2: The era of biologicals [J].

Beresford, M. W. ;

Baildam, E. M. .

ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION, 2009, 94 (05) :151-156

[6] STILL,S DISEASE IN ADULT [J].

BYWATERS, EG .

ANNALS OF THE RHEUMATIC DISEASES, 1971, 30 (02) :121-+

[7] Macrophage activation syndrome in juvenile idiopathic arthritis [J].

Cortis, Elisabetta ;

Insalaco, Antonella .

ACTA PAEDIATRICA, 2006, 95 :38-41

[8] Tocilizumab for multirefractory adult-onset Still's disease [J].

De Bandt, M. ;

Saint-Marcoux, B. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (01) :153-154

[9] Reactive hemophagocytic syndrome in adult systemic disease: Report of twenty-six cases and literature review [J].

Dhote, R ;

Simon, J ;

Papo, T ;

Detournay, B ;

Sailler, L ;

Andre, MH ;

Dupond, JL ;

Larroche, C ;

Piette, AM ;

Mechenstock, D ;

Ziza, JM ;

Arlaud, J ;

Labussiere, AS ;

Desvaux, A ;

Baty, V ;

Blanche, P ;

Schaeffer, A ;

Piette, JC ;

Guillevin, L ;

Boissonnas, A ;

Christoforov, B .

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2003, 49 (05) :633-639

[10] Pathogenesis and management of adult-onset Still's disease [J].

Efthimiou, Petros ;

Georgy, Sharon .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2006, 36 (03) :144-152

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