LncRNA ENSG00000254615 Modulates Proliferation and 5-FU Resistance by Regulating p21 and Cyclin D1 in Colorectal Cancer

被引：9

作者：

Fu, Yang ^{[1
,2
]}

Huang, Runqing ^{[1
,2
,3
]}

Li, Jianxia ^{[1
,2
]}

Xie, Xiaoyu ^{[1
]}

Deng, Yanhong ^{[1
,2
,3
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Med Oncol, Guangzhou, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Res Inst Gastroenterol, Guangzhou, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou, Peoples R China

来源：

CANCER INVESTIGATION | 2021年 / 39卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Colorectal cancer; lncRNA; proliferation; 5-FU resistance; LONG NONCODING RNAS; EXPRESSION;

D O I：

10.1080/07357907.2021.1923727

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

5-Fluorouracil (5-FU) resistance is an urgent problem of colorectal cancer (CRC) chemotherapy that needs to be resolved. To investigate 5-FU-associated lncRNAs for CRC might be of great significant. LncRNA ENSG00000254615 was detected by RNA-sequencing. ENSG00000254615 were detected highly expressed in 5-FU-sensitive CRC cells and tissue specimens, and inhibited cell proliferation and attenuated 5-FU resistance in vitro and in vivo. Furthermore, ENSG00000254615 participated in the regulation of p21 and Cyclin D1. Taken together, we proposed that ENSG00000254615 inhibits proliferation and attenuates 5-FU resistance of CRC by regulating p21 and Cyclin D1 expression.

引用

页码：696 / 710

页数：15

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