Bioactive compounds and their libraries: An insight into prospective phytotherapeutics approach for oral mucocutaneous cancers

被引：18

作者：

Adeola, Henry A. ^{[1
,2
,3
,4
]}

Bano, Afsareen ^{[5
]}

Vats, Ravina ^{[5
]}

Vashishtha, Amit ^{[6
]}

Verma, Deepika ^{[7
]}

Kaushik, Deepak ^{[8
]}

Mittal, Vineet ^{[8
]}

Rahman, Md. Habibur ^{[9
]}

Najda, Agnieszka ^{[10
]}

Albadrani, Ghadeer M. ^{[11
]}

Sayed, Amany A. ^{[12
]}

Farouk, Sameh M. ^{[13
]}

Hassanein, Emad H. M. ^{[14
]}

Akhtar, Muhammad Furqan ^{[15
]}

Saleem, Ammara ^{[16
]}

Abdel-Daim, Mohamed M. ^{[17
]}

Bhardwaj, Rashmi ^{[5
]}

机构：

[1] Univ Western Cape, Fac Dent, Dept Oral & Maxillofacial Pathol, Cape Town, South Africa

[2] Tygerberg Hosp, Cape Town, South Africa

[3] Univ Cape Town, Fac Hlth Sci, Div Dermatol, Dept Med, Cape Town, South Africa

[4] Univ Cape Town, Groote Schuur Hosp, Cape Town, South Africa

[5] Maharshi Dayanand Univ, Ctr Med Biotechnol, Rohtak, Haryana, India

[6] Univ Delhi, Sri Venkateswara Coll, Dept Bot, New Delhi, India

[7] AllMS, Dept Biochem, Delhi, India

[8] Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, Haryana, India

[9] Southeast Univ, Dept Pharm, Dhaka 1213, Bangladesh

[10] Univ Life Sci Lublin, Dept Vegetable Crops & Med Plants, 50A Doswiadczalna St, PL-20280 Lublin, Poland

[11] Princess Nourah bint Abdulrahman Univ, Dept Biol, Coll Sci, Riyadh 11474, Saudi Arabia

[12] Cairo Univ, Dept Zool, Fac Sci, Giza 12613, Egypt

[13] Suez Canal Univ, Cytol & Histol Dept, Fac Vet Med, Ismailia 41522, Egypt

[14] Al Azhar Univ, Dept Pharmacol & Toxicol, Fac Pharm, Assiut, Egypt

[15] Riphah Int Univ, Riphah Inst Pharmaceut Sci, Lahore Campus, Lahore, Pakistan

[16] Univ Faisalabad, Fac Pharmaceut Sci, Dept Pharmacol, Govt Coll, Faisalabad, Pakistan

[17] Suez Canal Univ, Dept Pharmacol, Fac Vet Med, Ismailia 41522, Egypt

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 141卷

关键词：

Bioactive compounds; Phytochemicals; Compound libraries; Oral mucocutaneous cancers; In-silico; CELL-CYCLE ARREST; IN-VITRO; COLORECTAL-CANCER; NASOPHARYNGEAL CARCINOMA; ANTICANCER ACTIVITY; LUNG-CANCER; APOPTOSIS; VIVO; CURCUMIN; GROWTH;

D O I：

10.1016/j.biopha.2021.111809

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Oral mucocutaneous cancers (OMCs) are cancers that affect both the oral mucosa and perioral cutaneous structures. Common OMCs are squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and malignant melanoma (MM). Anatomical similarities and conventions which categorizes these lesions blur the magnitude of OMCs in diverse populations. The burden of OMC is high in the sub-Saharan Africa and Indian subcontinents, and the cost of management is prohibitive in the resource-limited, developing world. Hence, there is a pressing demand for the use of cost-effective in silico approaches to identify diagnostic tools and treatment targets for diseases with high burdens in these regions. Due to their ubiquitousness and accessibility, the use of therapeutic efficacy of plant bioactive compounds in the management of OMC is both appropriate and plausible. Furthermore, screening known mechanistic disease targets with well annotated plant bioactive compound libraries is poised to improve the routine management of OMCs provided that the requisite access to database resources are available and accessible. Using natural products minimizes the side effects and morbidities associated with conventional therapies. The development of innovative treatments approaches would tremendously benefit the African and Indian populace and reduce the mortalities associated with OMCs in the developing world. Hence, we discuss herein, the potential benefits, opportunities and challenges of using bioactive compound libraries in the management of OMCs.

引用

页数：13

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