Use of π-acceptors in charge-transfer complexation of some cephalosporins:: Chloranilic acid as a spectrophotometric titrant in non-aqueous media

A spectrophotometric titration method is described for the determination of some cephalosporins and their dosage forms using 0.005 M chloranilic acid solution in 1,4-dioxane as the titrant. The end-points is determined by measuring the change in absorbance of the sample at 488-528 nm. Quantitative recoveries with good reproducibility are reported for cephalexin, cefadroxile, cefaclor, cefuroxime, cefoxitin, ceftazidine and ceftriaxone eight dosage forms. The least-squares method for the end point location in the spectrophotometric titration is also proposed.