Human embryonic stem cells as a model for nutritional programming: An evaluation

被引：17

作者：

Allegrucci, C ^{[1
]}

Denning, CN ^{[1
]}

Burridge, P ^{[1
]}

Steele, W ^{[1
]}

Sinclair, KD ^{[1
]}

Young, LE ^{[1
]}

机构：

[1] Univ Nottingham, Nottingham NG7 2UH, England

来源：

REPRODUCTIVE TOXICOLOGY | 2005年 / 20卷 / 03期

基金：

英国医学研究理事会;

关键词：

developmental origins of adult disease; embryo; nutritional programming; DNA methylation; human embryonic stem cells; folate;

D O I：

10.1016/j.reprotox.2005.04.010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Our laboratory is evaluating whether an epigenetic mechanism involving alterations in DNA methylation can alter the trajectory of embryonic/fetal development in response to maternal nutrients. A similar mechanism may operate in embryo culture environments commonly used in human assisted conception. Since developmental studies on early human embryos in utero are obviously not possible, we have begun to investigate the utility of human,embryonic stern cells (hESC) to uncover potential programming mechanisms. This review highlights some of the advantages and problems associated with such a model and suggests that these issues are also broadly applicable to utility of hESC for more general toxicology and drug screening applications. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：353 / 367

页数：15

共 136 条

[1] Unique gene expression signatures of independently-derived human embryonic stem cell lines [J].