NKT cells and HIV infection

被引：25
|
作者：
Unutmaz, D [1 ]
机构：
[1] Vanderbilt Univ, Sch Med, Med Ctr N, Dept Microbiol & Immunol, Nashville, TN 37232 USA
来源：
MICROBES AND INFECTION | 2003年 / 5卷 / 11期
关键词：
NKT cells; HIV-1infection; cytokines;
D O I：
10.1016/S1286-4579(03)00185-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer T (NKT) cells are a subset of lymphocytes that express a semi-invariant T cell receptor (TCR) that recognizes glycolipids presented by the non-polymorphic MHC class I-like molecule Md. NKT cells regulate a wide variety of immune functions against autoantigens and pathogens. Recently, it was shown that NKT cells are targeted by HIV-1 and selectively lost in HIV-infected individuals. This review will focus on the mechanisms, consequences and therapeutic implications of these findings. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：1041 / 1047
页数：7
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