Combined evaluation of the expression status of CD155 and TIGIT plays an important role in the prognosis of LUAD (lung adenocarcinoma)

被引：84

作者：

Sun, Yu ^{[1
]}

Luo, Jiping ^{[1
]}

Chen, Yangshan ^{[1
]}

Cui, Ji ^{[2
]}

Lei, Yiyan ^{[3
]}

Cui, Yongmei ^{[1
]}

Jiang, Neng ^{[1
]}

Jiang, Wenting ^{[1
]}

Chen, Lili ^{[1
]}

Chen, Yanyang ^{[1
]}

Kuang, Yukun ^{[4
]}

Tang, Kejing ^{[4
]}

Ke, Zunfu ^{[1
,5
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pathol, 58 ZhongShan Second Rd, Guangzhou 510080, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Gastrointestinal Surg Ctr, Guangzhou 510080, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Thorac Surg, Guangzhou 510080, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Resp Med, Guangzhou 510080, Guangdong, Peoples R China

[5] Sun Yat Sen Univ, Affiliated Hosp 1, Inst Precis Med, Guangzhou 510080, Guangdong, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2020年 / 80卷

基金：

中国国家自然科学基金;

关键词：

CD155; TIGIT; Immune checkpoint; LUAD; T-CELLS; CANCER STATISTICS; SURVIVAL; ADHESION; IMMUNOTHERAPY; STIMULATION; ASSOCIATION; MOLECULES; THERAPY; LIGANDS;

D O I：

10.1016/j.intimp.2020.106198

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interaction between CD155 and its high-affinity ligand TIGIT is being increasingly investigated in various solid tumors. However, the prognostic significance of CD155 and TIGIT in lung adenocarcinoma (LUAD) remains unclear. In this study, immunohistochemistry was applied in 334 LUAD cases to evaluate the expression of CD155 and TIGIT. Western blotting was conducted in 5 paired primary LUAD and adjacent normal lung tissues. Our results reveal that CD155 and TIGIT are overexpressed in LUAD tissues and that aberrant overexpression is closely correlated with poor clinical outcomes (P < 0.01). The multivariate model also shows that CD155 expression is an independent risk factor for LUAD (RR, 1.34; P = 0.036). Moreover, patients expressing high CD155 and TIGIT simultaneously presented shorter overall survival (OS) (P < 0.01) and progression-free survival (PFS) (P < 0.01). These findings suggest that CD155 and TIGIT can make up a prognosticating tool to predict clinical outcomes, thereby contributing to personalized medical care in LUAD.

引用

页数：10

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