European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics - Update 2019

被引：142

作者：

Garbe, Claus ^{[1
]}

Amaral, Teresa ^{[1
,2
]}

Peris, Ketty ^{[3
,4
]}

Hauschild, Axel ^{[5
]}

Arenberger, Petr ^{[6
]}

Bastholt, Lars ^{[7
]}

Bataille, Veronique ^{[8
]}

del Marmol, Veronique ^{[9
]}

Dreno, Brigitte ^{[10
]}

Fargnoli, Maria Concetta ^{[11
]}

Grob, Jean-Jacques ^{[12
]}

Hoeller, Christoph ^{[13
]}

Kaufmann, Roland ^{[14
]}

Lallas, Aimilios ^{[15
]}

Lebbe, Celeste ^{[16
]}

Malvehy, Josep ^{[17
]}

Middleton, Mark ^{[18
]}

Moreno-Ramirez, David ^{[19
]}

Pellacani, Giovanni ^{[20
]}

Saiag, Philippe ^{[21
]}

Stratigos, Alexander J. ^{[22
]}

Vieira, Ricardo ^{[23
]}

Zalaudek, Iris ^{[24
]}

Eggermont, Alexander M. M. ^{[25
]}

机构：

[1] Eberhard Karls Univ Tubingen, Ctr Dermatooncol, Dept Dermatol, Liebermeisterstr 25, D-72076 Tubingen, Germany

[2] Portuguese Air Force Hlth Care Direct, Lisbon, Portugal

[3] Univ Cattolica, Inst Dermatol, Rome, Italy

[4] Fdn Policlin Univ A Gemelli, IRCCS, Rome, Italy

[5] Univ Hosp Schleswig Holstein UKSH, Dept Dermatol, Campus Kiel, Kiel, Germany

[6] Charles Univ Prague, Fac Med 3, Dept Dermatovenerol, Prague, Czech Republic

[7] Odense Univ Hosp, Dept Oncol, Odense, Denmark

[8] Kings Coll London, Sch Basic & Med Biosci, Twin Res & Genet Epidemiol Unit, London SE1 7EH, England

[9] Univ Libre Bruxelles, Erasme Hosp, Dept Dermatol, Brussels, Belgium

[10] Univ Nantes, Dermatol Dept, CRCINA, CHU Nantes,CIC 1413, Nantes, France

[11] Univ LAquila, Dept Dermatol, Laquila, Italy

[12] Univ Dept Dermatol, Marseille, France

[13] Med Univ Vienna, Dept Dermatol, Vienna, Austria

[14] Frankfurt Univ Hosp, Dept Dermatol Venerol & Allergol, Frankfurt, Germany

[15] Aristotle Univ Thessaloniki, Dept Dermatol 1, Thessaloniki, Greece

[16] Univ Paris 7 Diderot, St Louis Univ Hosp, AP HP, Dept Dermatol,INSERM U976, Paris, France

[17] IDIBAPS, Dept Dermatol, Melanoma Unit, Hosp Clin, Barcelona, Spain

[18] Univ Oxford, Biomed Res Ctr, NIHR, Oxford, England

[19] Hosp Univ Virgen Macarena, Med & Surg Dermatol Serv, Seville, Spain

[20] Univ Modena & Reggio Emilia, Dermatol Unit, Modena, Italy

[21] Univ Versailles St Quentin En Yvelines, Univ Dept Dermatol, AP HP, Boulogne, France

[22] Univ Athens, Andreas Sygros Hosp, Dept Dermatol 1, Sch Med, Athens, Greece

[23] Ctr Hosp Univ Coimbra, Dept Dermatol & Venereol, Coimbra, Portugal

[24] Univ Trieste, Maggiore Hosp, Dermatol Clin, Trieste, Italy

[25] Princess Maxima Ctr, NL-3584 CS Utrecht, Netherlands

来源：

EUROPEAN JOURNAL OF CANCER | 2020年 / 126卷

关键词：

Cutaneous melanoma; Primary diagnosis; AJCC classification; Dermatoscopy; Sequential digital dermatoscopy; Total body photography; Confocal reflectance microscopy; Imaging diagnostics; Mutation testing; Follow-up examinations; REFLECTANCE CONFOCAL MICROSCOPY; AMERICAN JOINT COMMITTEE; NEEDLE-ASPIRATION-CYTOLOGY; ACRAL LENTIGINOUS MELANOMA; TOTAL-BODY PHOTOGRAPHY; SENTINEL-NODE BIOPSY; MALIGNANT-MELANOMA; FOLLOW-UP; CUTANEOUS MELANOMA; MELANOCYTIC NEVI;

D O I：

10.1016/j.ejca.2019.11.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cutaneous melanoma (CM) is potentially the most dangerous form of skin tumor and causes 90% of skin cancer mortality. A unique collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization of Research and Treatment of Cancer (EORTC) was formed to make recommendations on CM diagnosis and treatment, based on systematic literature reviews and the experts' experience. The diagnosis of melanoma can be made clinically and shall always be confirmed through dermatoscopy. If a melanoma is suspected, a histopathological examination is required. Sequential digital dermatoscopy and full-body photography can be used in risk persons to detect the development of melanomas at an earlier stage. Where available, confocal reflectance microscopy can improve clinical diagnosis in special cases. Melanoma shall be classified according to the 8th version of the AJCC classification. Thin melanomas up to 0.8 mm tumor thickness does not require further imaging diagnostics. From stage IB onwards, examinations with lymph node sonography are recommended, but no further imaging examinations. From stage IIC whole-body examinations with CT or PET-CT in combination with brain MRI are recommended. From stage III and higher, mutation testing is recommended, particularly for BRAF V600 mutation. It is important to provide a structured follow-up to detect relapses and secondary primary melanomas as early as possible. There is no evidence to support the frequency and extent of examinations. A stage-based follow-up scheme is proposed, which, according to the experience of the guideline group, covers the minimum requirements; further studies may be considered. This guideline is valid until the end of 2021. (C) 2019 Published by Elsevier Ltd.

引用

页码：141 / 158

页数：18

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