Neuroendocrine differentiation in primary Merkel cell carcinoma -: Possible prognostic significance

被引：0
作者：
Koljonen, V
Haglund, C
Tukiainen, E
Böhling, T
机构：
[1] Helsinki Univ Hosp, Toolo Hosp, Dept Plast Surg, FIN-00029 Helsinki, Finland
[2] Helsinki Univ Hosp, Dept Gastroenterol & Gen Surg 2, FIN-00029 Helsinki, Finland
[3] HUSLAB, FIN-00029 Helsinki, Finland
[4] Univ Helsinki, Dept Pathol, FIN-00029 Helsinki, Finland
来源：
ANTICANCER RESEARCH | 2005年 / 25卷 / 2A期
关键词：
primary neuroendocrine carcinoma; Merkel cell carcinoma; neuroendocrine differentiation; prognosis; chromogranin-A;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The aim of this study was to examine the level of neuroendocrine differentiation to determine its association with clinicopathological parameters. Patients and Methods: Twenty-five primary MCC samples were evaluated for neuroendocrine differentiation profiles by immunohistochemistry using antibodies to chromogranin-A, microtubule associated protein-2 and synaptophysin. The data were compared with clinical parameters to find out whether their expression correlates with prognosis. Results: In general, MCC shows a high degree of neuroendocrine differentiation. A higher expression of chromogranin-A and synaptophysin associated with benign behaviour. Chromogranin-A appeared to be the most important one in predicting the course of disease. Conclusion: Low levels of neuroendocrine differentiation in MCC associates with poor prognosis. Chromogranin A could be used to identify patients who might benefit from oncological treatments.
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收藏
页码：853 / 858
页数：6
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